| Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications. | |
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MedLine Citation:
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PMID: 19478465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with hematological malignancies frequently suffer from lung diseases as a complication. However, it is difficult to discriminate leukemic invasion into the lung from infectious pulmonary complications. The serum level of Krebs von den Lungen-6 (KL-6), which is a mucin-like glycoprotein, is increased in more than 70% of patients with interstitial pneumonia. Surfactant protein-D (SP-D) is produced mainly in the lung by alveolar type II and bronchiolar epithelial cells and is a useful serum marker for interstitial pneumonia. We therefore measured the levels of KL-6 and SP-D in sera from 128 patients (76 males and 52 females, mean age: 59 years) with hematological malignancies, including adult T-cell leukemia (ATL). Overall, the increase in KL-6 or SP-D, above each cut-off value (500 U/ml for KL-6 and 110 ng/ml for SP-D), was detected in 11 patients (8.6%) or 10 patients (7.8%), respectively. In contrast, among 67 ATL patients, 15 patients had high serum levels of KL-6 and/or SP-D; both were elevated in 2 patients, only KL-6 was elevated in 6 patients and only SP-D was elevated in 7 patients. Thus, serum KL-6 and SP-D appear to be elevated in a mutually exclusive manner in ATL. Indeed, high serum levels of KL-6 were closely related to the stage of ATL, while the serum SP-D was elevated in ATL patients with pulmonary infection. In conclusion, the combined measurement of KL-6 and SP-D in ATL may become a useful means to discriminate leukemic pulmonary lesions from infectious pulmonary complications. |
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Authors:
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Akemi Osaka; Katsunori Yanagihara; Yasuaki Yamada; Hiroo Hasegawa; Naoko Inokuchi; Tomayoshi Hayashi; Minori Komoda; Shigeki Nakamura; Muneo Aoyama; Takashi Sawada; Shimeru Kamihira |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 218 ISSN: 1349-3329 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-29 Completed Date: 2009-08-13 Revised Date: 2013-01-03 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: Japan |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Flow Cytometry Humans Leukemia-Lymphoma, Adult T-Cell / blood*, complications*, pathology Lung Diseases / blood*, complications*, pathology Male Middle Aged Mucin-1 / blood* Pulmonary Surfactant-Associated Protein D / blood* |
| Chemical | |
Reg. No./Substance:
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0/MUC1 protein, human; 0/Mucin-1; 0/Pulmonary Surfactant-Associated Protein D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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