| Elevation of Na+-K+ ATPase immunoreactivity in GABAergic neurons in gerbil CA1 region following transient forebrain ischemia. | |
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MedLine Citation:
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PMID: 12834889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study, we suggested that GABAergic neurons might be resistant to ischemic insult, because of the maintenance of the GABA shunt, which is one of the ATP synthetic pathways in neurons. In the present study, we identified Na(+)-K(+) ATPase immunoreactivity in the gerbil hippocampus in order to determine whether changes in Na(+)-K(+) ATPase immunoreactivity correlate with GABA shunt following ischemic insult. At 12 h after ischemia-reperfusion, Na(+)-K(+) ATPase immunoreactivity accumulated in some neurons in the CA1 region. However, the protein content of Na(+)-K(+) ATPase was not altered. Interestingly, the density of Na(+)-K(+) ATPase immunoreactivity in neurons and the protein content in the CA1 region was intensified in the 24 h post-ischemic group. As a result of double immunofluorescence study, Na(+)-K(+) ATPase immunoreactive neurons were identified with GABAergic neurons. Therefore, our findings suggest that the increase of Na(+)-K(+) ATPase in GABAergic neurons may be able to explain the resistance of these cells to ischemic insult, and support our previous hypothesis that GABA may play an important role as a metabolite in the survival of GABAergic neurons after ischemic insult. |
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Authors:
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Tae-Cheon Kang; In Koo Hwang; Seung-Kook Park; Sung-Jin An; Young Sam Nam; Do-Hoon Kim; In Se Lee; Moo Ho Won |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 977 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-01 Completed Date: 2003-09-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: IM |
Affiliation:
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Department of Anatomy, College of Medicine, Hallym University, Kangwon-Do, Chunchon 200-702, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Gerbillinae Glutamate Decarboxylase / metabolism Hippocampus / anatomy & histology, enzymology* Immunohistochemistry Ischemic Attack, Transient / enzymology*, metabolism Male Sodium-Potassium-Exchanging ATPase / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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