| Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis. | |
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MedLine Citation:
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PMID: 20536328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the clinical value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction (LVDD) associated with maintenance haemodialysis (MHD) population. METHODS: Plasma BNP was determined in 59 MHD patients with normal ejection fraction. The ratio of early to late annular velocity (E'/A') was determined by tissue Doppler imaging as a parameter of diastolic function. RESULTS: LVDD occurred in 66% of the patients. Receiver-operating characteristic curve analyses identified a cut-off of 353.6 pg ml(-1) as the one with the highest sensitivity and specificity for detecting LVDD. CONCLUSIONS: Plasma BNP may serve as a potential biomarker in diagnosing LVDD in MHD patients with normal systolic function. |
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Authors:
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Hong Liu; Ying-Zi Zhang; Min Gao; Bi-Cheng Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Volume: 15 ISSN: 1366-5804 ISO Abbreviation: Biomarkers Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606000 Medline TA: Biomarkers Country: England |
Other Details:
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Languages: eng Pagination: 533-7 Citation Subset: IM |
Affiliation:
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Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiangsu Province, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Area Under Curve Biological Markers / blood Echocardiography, Doppler Female Humans Kidney Failure, Chronic / complications, therapy Male Middle Aged Natriuretic Peptide, Brain / blood* ROC Curve Renal Dialysis* Ventricular Dysfunction, Left / blood*, complications Ventricular Function, Left / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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