Document Detail

Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis.
MedLine Citation:
PMID:  20536328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the clinical value of B-type natriuretic peptide (BNP) in diagnosing left ventricular diastolic dysfunction (LVDD) associated with maintenance haemodialysis (MHD) population.
METHODS: Plasma BNP was determined in 59 MHD patients with normal ejection fraction. The ratio of early to late annular velocity (E'/A') was determined by tissue Doppler imaging as a parameter of diastolic function.
RESULTS: LVDD occurred in 66% of the patients. Receiver-operating characteristic curve analyses identified a cut-off of 353.6 pg ml(-1) as the one with the highest sensitivity and specificity for detecting LVDD.
CONCLUSIONS: Plasma BNP may serve as a potential biomarker in diagnosing LVDD in MHD patients with normal systolic function.
Hong Liu; Ying-Zi Zhang; Min Gao; Bi-Cheng Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  533-7     Citation Subset:  IM    
Institute of Nephrology, Zhong Da Hospital, Southeast University, Nanjing, Jiangsu Province, China.
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MeSH Terms
Area Under Curve
Biological Markers / blood
Echocardiography, Doppler
Kidney Failure, Chronic / complications,  therapy
Middle Aged
Natriuretic Peptide, Brain / blood*
ROC Curve
Renal Dialysis*
Ventricular Dysfunction, Left / blood*,  complications
Ventricular Function, Left / physiology
Young Adult
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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