| Elevation of adipsin, a complement activating factor, in the mouse placenta during spontaneous abortion. | |
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MedLine Citation:
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PMID: 20581430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complement system is thought to be precisely regulated during pregnancy. We have examined specific gene profiles in mouse placentas causing spontaneous abortion and found notable up-regulation of adipsin, a complement activating factor. The aim of the present study was to determine the basic kinetics and localization of adipsin in the placenta and the difference in complement activity between normal placentas and placentas of abortuses. Normal and spontaneously absorbed implantation sites obtained from naturally-mated mouse uteri on days 10.5 and 14.5 of pregnancy were processed for histologic studies and protein purification. Adipsin immunoreaction was detected at the decidua basalis in normal placentas and additionally at the placental labyrinth in the absorbed placentas. The quantity of adipsin was increased in the absorbed placentas compared with the normal placentas. In concert with the increase in adipsin, the amounts of complement component 3 and degradation products were elevated and complemental activity was up-regulated in the absorbed placenta. These findings suggest that local expression of adipsin has a reproductive effect at the feto-maternal interface and possibly plays a role in spontaneous abortion. |
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Authors:
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Ai TAKESHITA; Tomohiro KONDO; Toshiya OKADA; Ken Takeshi KUSAKABE |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-23 |
Journal Detail:
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Title: The Journal of reproduction and development Volume: 56 ISSN: 0916-8818 ISO Abbreviation: J. Reprod. Dev. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438792 Medline TA: J Reprod Dev Country: Japan |
Other Details:
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Languages: eng Pagination: 508-14 Citation Subset: IM |
Affiliation:
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Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University, Osaka 598-8531, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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metabolism* Animals Complement Activation / physiology* Complement C3 / metabolism Complement Factor D / metabolism Female Immunohistochemistry Mice Mice, Inbred C57BL Placenta / metabolism* Pregnancy Uterus / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; EC 3.4.21.46/Complement Factor D; EC 3.4.21.46/complement factor D, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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