Document Detail

Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease.
MedLine Citation:
PMID:  17382553     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. METHODS AND RESULTS: Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means+/-SD: 7.5+/-1.8 vs. 6.1+/-1.1 G/L, p<0.001; 7.7+/-20.7 vs. 2.5+/-1.9 mg/L, p=0.015; and 3.7+/-0.9 vs. 3.1+/-0.5 g/L, p<0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1+/-22.9 and 19.9+/-15.3 EU/mL, p=0.6; and 19+/-15 vs. 20+/-9 U/mL, p=0.07) and RANTES and MCP-1 levels (72.4+/-32.3 vs. 73.8+/-27.3 ng/mL, p=0.7; and 468+/-1041 vs. 318+/-131 pg/mL, p=0.7) did not differ significantly between patients and controls and did not correlate with IMT. CONCLUSIONS: Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.
Mária Tünde Magyar; Dániel Bereczki; István Csípo; Edit Gyimesi; László Csiba; Attila Valikovics; József Balla; Sándor Sipka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-26
Journal Detail:
Title:  Cytokine     Volume:  37     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-06-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Department of Neurology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary.
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MeSH Terms
Age of Onset
Antibodies / immunology
Biological Markers
C-Reactive Protein / metabolism*
Carotid Artery Diseases / metabolism*,  pathology
Chemokine CCL2 / blood*
Chemokine CCL5 / blood*
Endothelial Cells / immunology*
Fibrinogen / metabolism*
Leukocyte Count
Lipoproteins, LDL / immunology*
Middle Aged
Reg. No./Substance:
0/Antibodies; 0/Biological Markers; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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