| Elevated vitamin B(12) levels in autoimmune lymphoproliferative syndrome attributable to elevated haptocorrin in lymphocytes. | |
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MedLine Citation:
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PMID: 22306884 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Identify the etiology of elevated B(12) in autoimmune lymphoproliferative syndrome (ALPS). DESIGN: Peripheral blood of ALPS patients with elevated B(12) and controls were evaluated. RESULTS: Total and holo-haptocorrin (HC) levels were 26- and 23-fold higher in ALPS patients, respectively. No abnormal B(12)-binding proteins were found. Western blot revealed HC in lymphocyte lysates only from ALPS patients. CONCLUSION: Elevated concentrations of B(12) found in ALPS patients were due to increased lymphocyte expression of HC. |
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Authors:
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Raffick A R Bowen; Kennichi C Dowdell; Janet K Dale; Steven K Drake; Thomas A Fleisher; Glen L Hortin; Alan T Remaley; Ebba Nexo; V Koneti Rao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-28 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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