| Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 21493719 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is a strong correlation between increased vertebral artery resistance and arterial pressure in humans. The reasons for this increased resistance at high systemic pressure remain unknown but may include raised sympathetic activity. With the finding that pre-hypertensive spontaneously hypertensive (PHSH) rats, which have raised sympathetic nerve activity but a blood pressure comparable to normotensive rat strains, we hypothesised that its vertebrobasilar vascular resistance would already be raised and, as a consequence, would exhibit a more responsive Cushing response (e.g. brain ischemia evoked sympathoexcitation/pressor response). We report that PHSH rats exhibited a remodelling of the basilar artery (i.e. increased wall thickness, lower lumen-to-wall thickness ratio) that occurred before the onset of hypertension. In a novel in vitro vascularly isolated, arterially perfused brainstem preparation of PHSH rats (4-5 weeks old), brainstem vascular resistance was raised by ~35% relative to age-/sex- matched normotensive rats (P< 0.05). In the in situ arterial perfused brainstem preparation, occlusion of both vertebral arteries in the PHSH rat resulted in a significantly greater increase in sympathetic activity (57% vs. 20% PHSH: control respectively; p<0.01) that triggered a greater increase in arterial perfusion pressure (8 vs. 3 mmHg PHSH: control; P<0.01) compared to normotensive rats. These data indicate raised vertebrobasilar artery resistance prior to the onset of hypertension in the PHSH rat. With the raised responsiveness of the Cushing Response in the PHSH rat, we discuss the possibility of brainstem perfusion as a central nervous system determinant of the set-point of vasomotor sympathetic tone in the hypertensive condition. |
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Authors:
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Matthew J Cates; Peter W Steed; Ana P L Abdala; Philip D Langton; Julian F R Paton |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-14 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Bristol. |
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