Document Detail

Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats.
MedLine Citation:
PMID:  21493719     Owner:  NLM     Status:  MEDLINE    
There is a strong correlation between increased vertebral artery resistance and arterial blood pressure in humans. The reasons for this increased resistance at high systemic pressure remain unknown, but may include raised sympathetic activity. With the recent finding that prehypertensive spontaneously hypertensive (PHSH) rats, which have raised sympathetic nerve activity, but a blood pressure comparable to normotensive rat strains, we hypothesized that its vertebrobasilar vascular resistance would already be raised and, as a consequence, would exhibit a more responsive Cushing response (e.g., brain ischemia evoked sympathoexcitation and a pressor response). We report that PHSH rats exhibited a remodeling of the basilar artery (i.e., increased wall thickness and lower lumen-to-wall thickness ratio) that occurred before the onset of hypertension. In a novel in vitro vascularly isolated, arterially perfused brain stem preparation of PHSH rats of 4-5 wk of age, brain stem vascular resistance was raised by ∼35% relative to age- and sex-matched normotensive rats (P < 0.05). In the in situ arterial perfused working heart-brain stem preparation, occlusion of both vertebral arteries in the PHSH rat resulted in a significantly greater increase in sympathetic activity (57 vs. 20%, PHSH vs. control; P < 0.01) that triggered a greater increase in arterial perfusion pressure (8 vs. 3 mmHg, PHSH vs. control; P < 0.01) compared with normotensive rats. These data indicate raised vertebrobasilar artery resistance before the onset of hypertension in the PHSH rat. With the raised responsiveness of the Cushing response in the PHSH rat, we discuss the possibility of brain stem perfusion as a central nervous system determinant of the set point of vasomotor sympathetic tone in the hypertensive condition.
Matthew J Cates; Peter W Steed; Ana P L Abdala; Philip D Langton; Julian F R Paton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-14
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  111     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2013-07-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-56     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Newborn
Basilar Artery / pathology,  physiopathology*
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cerebrovascular Circulation*
Disease Models, Animal
Prehypertension / pathology,  physiopathology*
Rats, Inbred SHR
Rats, Wistar
Sympathetic Nervous System / physiopathology
Vascular Resistance*
Vertebral Artery / physiopathology*
Grant Support
HL033610/HL/NHLBI NIH HHS; R37 HL033610/HL/NHLBI NIH HHS; RG/07/006/23634//British Heart Foundation; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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