Document Detail

Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity.
MedLine Citation:
PMID:  8862515     Owner:  NLM     Status:  MEDLINE    
Abnormally high postabsorptive venous plasma glutamate levels have been reported for several diseases that are associated with a loss of body cell mass including cancer, human/simian immunodeficiency virus infection, and amyotrophic lateral sclerosis. Studies on exchange rates in well-nourished cancer patients now show that high venous plasma glutamate levels may serve as a bona fide indicator for a decreased uptake of glutamate by the peripheral muscle tissue in the postabsorptive period and may be indicative for a precachectic state. High glutamate levels are also moderately correlated with a decreased uptake of glucose and ketone bodies. Relatively high venous glutamate levels have also been found in non-insulin-dependent diabetes mellitus and to some extent also in the cubital vein of normal elderly subjects, i.e., in conditions commonly associated with a decreased glucose tolerance and progressive loss of body cell mass.
V Hack; O Stütz; R Kinscherf; M Schykowski; M Kellerer; E Holm; W Dröge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  74     ISSN:  0946-2716     ISO Abbreviation:  J. Mol. Med.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-09     Completed Date:  1996-12-09     Revised Date:  2011-07-08    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  337-43     Citation Subset:  IM; X    
Department of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
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MeSH Terms
ATP-Binding Cassette Transporters / metabolism*
Amino Acid Transport System X-AG
Biological Markers
Cachexia / blood*,  etiology
Cations / metabolism
Diabetes Mellitus, Type 2 / complications
Glucose / metabolism
Glutamates / blood*,  physiology
Ketone Bodies / metabolism
Middle Aged
Muscle, Skeletal / metabolism
Neoplasms / complications,  metabolism*
Sodium / metabolism
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Amino Acid Transport System X-AG; 0/Biological Markers; 0/Cations; 0/Glutamates; 0/Ketone Bodies; 50-99-7/Glucose; 7440-23-5/Sodium

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