Document Detail

Elevated urinary free cortisol in patients with dementia.
MedLine Citation:
PMID:  2052129     Owner:  NLM     Status:  MEDLINE    
Urinary free cortisol (UFC), 17-hydroxycorticosteroids (17-OHCS) in urine and dexamethasone suppression test (DST) were examined in patients with dementia of Alzheimer type (DAT) and multi-infarct dementia (MID), and nondemented elderly. Eight of 19 patients (42.1%) were DST nonsuppressor. UFC was significantly elevated in patients with dementia, compared with that in nondemented elderly. There was no difference in UFC levels between DAT and MID. The UFC level correlated with post-DST plasma cortisol level at 1600 in demented patients. The mean level of 17-OHCS in demented patients was increased, although the difference was not significant statistically. In demented patients, UFC levels, not 17-OHCS levels in urine were correlated with Mini-Mental State Examination scores. These results suggest that a hypothalamo-pituitary-adrenal axis function is activated in demented patients and that this activation relates generally to dementation itself, not to an etiology of dementia. Measurement of UFC might be a biological marker of dementia and may have a value in diagnosis of dementia.
K Maeda; K Tanimoto; T Terada; T Shintani; T Kakigi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobiology of aging     Volume:  12     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-3     Citation Subset:  IM    
Hyogo Institute for Research in Adult Diseases, Himeji.
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MeSH Terms
17-Hydroxycorticosteroids / urine
Aged, 80 and over
Alzheimer Disease / urine*
Dementia, Multi-Infarct / urine*
Dexamethasone / diagnostic use
Hydrocortisone / blood,  urine*
Psychiatric Status Rating Scales
Reg. No./Substance:
0/17-Hydroxycorticosteroids; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone

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