Document Detail

Elevated urinary 19-Nor-deoxycorticosterone glucuronide in Cushing's syndrome.
MedLine Citation:
PMID:  3558730     Owner:  NLM     Status:  MEDLINE    
Hypertension is a common finding in patients with Cushing's syndrome (CS), but the cause is unknown. One possibility is excess production of nonaldosterone mineralocorticoids, such as 19-nor-deoxycorticosterone (19-Nor-DOC). To evaluate this possibility we measured urinary 19-Nor-DOC glucuronide in normal subjects (n = 14) and patients with essential hypertension (n = 10), pituitary-dependent CS (n = 8), and adrenal tumors producing CS (n = 6). The subjects were admitted to a metabolic unit where 24-h urine samples were collected while they ate an isocaloric diet (128 meq Na+ 80 meq K+/day). 19-Nor-DOC glucuronide was purified by extraction and chromatography and measured by RIA. Urinary 19-Nor-DOC glucuronide excretion was significantly higher in patients with both pituitary CS and adrenal CS compared to that in normal subjects, while the values in the two CS groups were similar. The patients with essential hypertension also had elevated urinary 19-Nor-DOC glucuronide excretion, although the values were lower than those in either CS group. These results demonstrate that a nonaldosterone mineralocorticoid, 19-Nor-DOC, is produced in excess in patients with either pituitary or adrenal CS and, thus, suggest a possible role for 19-Nor-DOC in the pathogenesis of some hypertensive disorders.
M E Ehlers; G T Griffing; T E Wilson; J C Melby
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  926-30     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / complications
Adrenal Cortex Neoplasms / complications
Aldosterone / metabolism
Carcinoma / complications
Cushing Syndrome / complications,  urine*
Desoxycorticosterone / analogs & derivatives*,  urine
Hydrocortisone / urine
Hypertension / etiology,  urine*
Middle Aged
Pituitary Neoplasms / complications
Potassium / blood
Grant Support
Reg. No./Substance:
0/19-nordeoxycorticosterone glucosiduronate; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 567-03-3/tetrahydrodeoxycorticosterone; 64-85-7/Desoxycorticosterone; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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