Document Detail


Elevated urinary 19-Nor-deoxycorticosterone glucuronide in Cushing's syndrome.
MedLine Citation:
PMID:  3558730     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a common finding in patients with Cushing's syndrome (CS), but the cause is unknown. One possibility is excess production of nonaldosterone mineralocorticoids, such as 19-nor-deoxycorticosterone (19-Nor-DOC). To evaluate this possibility we measured urinary 19-Nor-DOC glucuronide in normal subjects (n = 14) and patients with essential hypertension (n = 10), pituitary-dependent CS (n = 8), and adrenal tumors producing CS (n = 6). The subjects were admitted to a metabolic unit where 24-h urine samples were collected while they ate an isocaloric diet (128 meq Na+ 80 meq K+/day). 19-Nor-DOC glucuronide was purified by extraction and chromatography and measured by RIA. Urinary 19-Nor-DOC glucuronide excretion was significantly higher in patients with both pituitary CS and adrenal CS compared to that in normal subjects, while the values in the two CS groups were similar. The patients with essential hypertension also had elevated urinary 19-Nor-DOC glucuronide excretion, although the values were lower than those in either CS group. These results demonstrate that a nonaldosterone mineralocorticoid, 19-Nor-DOC, is produced in excess in patients with either pituitary or adrenal CS and, thus, suggest a possible role for 19-Nor-DOC in the pathogenesis of some hypertensive disorders.
Authors:
M E Ehlers; G T Griffing; T E Wilson; J C Melby
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  64     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  926-30     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma / complications
Adrenal Cortex Neoplasms / complications
Adult
Aged
Aldosterone / metabolism
Carcinoma / complications
Cushing Syndrome / complications,  urine*
Desoxycorticosterone / analogs & derivatives*,  urine
Female
Humans
Hydrocortisone / urine
Hypertension / etiology,  urine*
Male
Middle Aged
Pituitary Neoplasms / complications
Potassium / blood
Grant Support
ID/Acronym/Agency:
5RO1-AM-12027-18/AM/NIADDK NIH HHS; HL-07224/HL/NHLBI NIH HHS; HL-18318-11/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/19-nordeoxycorticosterone glucosiduronate; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 567-03-3/tetrahydrodeoxycorticosterone; 64-85-7/Desoxycorticosterone; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels.
Next Document:  Thyroxine and 3,5,3'-triiodothyronine content of thyroglobulin in thyroid needle aspirates in hypert...