| Elevated uric acid correlates with wound severity. | |
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MedLine Citation:
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PMID: 21973196 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. We have also shown a corresponding depletion in UA precursors, including adenosine, with increased wound severity. Further, we have shown that xanthine oxidase, the only enzyme in humans that catalyses the production of UA in conjunction with a burst of free radicals, is active in chronic WF. Taken together, this provides compelling evidence that xanthine oxidase may play a critical role in the formation of chronic wounds by prolonging the inflammatory process. |
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Authors:
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Melissa L Fernandez; Zee Upton; Helen Edwards; Kathleen Finlayson; Gary K Shooter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-4 |
Journal Detail:
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Title: International wound journal Volume: - ISSN: 1742-481X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230907 Medline TA: Int Wound J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc. |
Affiliation:
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ML Fernandez, PhD, Tissue Repair and Regeneration Program, Cells and Tissues Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia Z Upton, PhD, Tissue Repair and Regeneration Program, Cells and Tissues Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia H Edwards, PhD, Faculty of Health, School of Nursing and Midwifery, Human Health and Wellbeing Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia K Finlayson, PhD, Faculty of Health, School of Nursing and Midwifery, Human Health and Wellbeing Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia GK Shooter, PhD, Tissue Repair and Regeneration Program, Cells and Tissues Domain, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. |
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