| Elevated type IV collagen in bronchoalveolar lavage fluid from infants with bronchopulmonary dysplasia. | |
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MedLine Citation:
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PMID: 11150828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured the levels of type IV collagen and lipid peroxides in bronchoalveolar lavage fluid (BALF) from infants with respiratory distress syndrome (RDS) to determine the relationship to the development of bronchopulmonary dysplasia (BPD). We analyzed their levels between two groups, RDS infants who developed BPD (n = 8, BPD group) and those who did not (n = 11, RDS group). The levels of the type IV collagen in the BPD group were significantly higher than those in the RDS group at 3 and 7 days of age (p = 0.0024). In the BPD group, persistently increased levels of the type IV collagen were observed during the period up to 14 days of age. There was a positive relationship between the type IV collagen levels and polymorphonuclear leukocyte counts, and thiobarbituric acid-reactive substance levels in BALF. These results suggest that the increased type IV collagen levels in BALF of BPD infants may reflect pulmonary basement membrane damage and the involvement of oxygen metabolites in its process. |
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Authors:
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Y Ohki; M Kato; H Kimura; Y Nako; K Tokuyama; A Morikawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 79 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-02-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Bronchoalveolar Lavage Fluid / chemistry*, cytology Bronchopulmonary Dysplasia / metabolism* Collagen / analysis* Gestational Age Humans Infant, Newborn Infant, Premature* Leukocyte Count Neutrophils Respiration, Artificial Respiratory Distress Syndrome, Newborn / metabolism Thiobarbituric Acid Reactive Substances / analysis |
| Chemical | |
Reg. No./Substance:
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0/Thiobarbituric Acid Reactive Substances; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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