| Elevated systemic neutrophil count in diabetic retinopathy and diabetes: a hospital-based cross-sectional study on 30,793 Korean subjects. | |
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MedLine Citation:
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PMID: 21873679 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose:To evaluate the association between systemic parameters including inflammatory markers and diabetic retinopathy (DR).Methods:Cross-sectional study of 30,793 people who visited a healthcare center for medical checkup. Diabetic patients were classified into five DR groups: no DR, mild, moderate, severe non-proliferative and proliferative DR. Full laboratory work-up and comprehensive medical data of subjects were obtained and used for analysis.Results:The mean (SD) age of total participants was 47.4 (11.9) years (range: 18 - 90 years) and the male-to-female ratio was 55.7: 44.3. The prevalence of diabetes and DR were 6.6% (2,020/30,793) and 5.3% (108/2,020), respectively. Among inflammatory markers, the mean absolute neutrophil count (ANC,/μL) was significantly higher in the DR than the non-DR group (3,900 vs 3,566, P=0.0143) and in diabetic than non-diabetic subjects (3,583 vs 3,262, P<0.0001). Subjects in the fourth quintile groups of ANC showed 2.7 odds of having DR by multivariable analysis and there was a linear trend in the odds ratios according to increasing ANC levels. The level of ANC and ANC/leukocyte ratio also demonstrated a linearly increasing trend with the severity of DR even after adjusting for other clinical factors including HbA1c. Among significant risk factors of DR, ANC showed the second strongest prediction power for DR (AUROC=0.590) next to HbA1C (0.624).Conclusions:Elevated systemic neutrophil count is associated with the presence and severity of DR as well as diabetes. This result indicates that systemic subclinical inflammation is related with DR and neutrophil-mediated inflammation may play an important role in the pathogenesis of DR. |
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Authors:
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Se Joon Woo; Seong Joon Ahn; Jeeyun Ahn; Kyu Hyung Park; Kiheon Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-27 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang HospitalSeongnam, Korea. |
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