Document Detail

Elevated sympathetic nerve activity in patients with accelerated essential hypertension.
MedLine Citation:
PMID:  8325991     Owner:  NLM     Status:  MEDLINE    
To determine if an abnormality exists in the sympathetic nervous system of patients with accelerated hypertension, we recorded muscle sympathetic nerve activity (MSNA) from the tibial nerve by microneurography in eight benign essential hypertensives and seven accelerated essential hypertensives. Basal MSNA, plasma renin activity, and plasma angiotensin II levels were significantly higher in accelerated hypertensives than in benign hypertensives (P < 0.05). To clarify the relationship between the renin-angiotensin axis and sympathetic nervous system in the accelerated hypertensives, we measured the MSNA after 7 d of oral administration of captopril (75 mg/d) for antihypertensive treatment in the benign hypertensives and accelerated hypertensives. After administering captopril, the arterial pressure decreased significantly in the benign hypertensives and accelerated hypertensives with decreases in plasma angiotensin II levels, and the decreases in arterial pressure were greater in the accelerated hypertensive than in the benign hypertensives. After captopril administration, the MSNA decreased significantly in the accelerated hypertensives but did not change in the benign hypertensives. Thus, in accelerated hypertensives, sympathetic tone is elevated, and the elevated sympathetic tone is closely related to the activated renin-angiotensin axis tone.
T Matsukawa; T Mano; E Gotoh; M Ishii
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  92     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-8     Citation Subset:  AIM; IM    
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
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MeSH Terms
Angiotensin II / physiology
Blood Pressure / drug effects
Captopril / pharmacology
Heart Rate / drug effects
Hypertension / physiopathology*
Renin / physiology
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 62571-86-2/Captopril; EC

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