Document Detail


Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey.
MedLine Citation:
PMID:  23036645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Experimental and observational studies suggest a role for uric acid in non-alcoholic fatty liver disease (NAFLD). We examined the association between serum uric acid levels and NAFLD in a large population-based study from the United States.
MATERIALS/METHODS: A cross-sectional analysis of 10,732 nondiabetic adults who participated in the National Health and Nutrition Examination Survey 1988-1994. Sex specific uric acid quartiles were defined: ≤5.2, 5.3-6.0, 6.1-6.9, and >6.9mg/dL for men and ≤3.7, 3.8-4.5, 4.6-5.3, and >5.3mg/dL for women. NAFLD presence and severity were defined by ultrasonographic detection of steatosis in the absence of other liver diseases. We modeled the probability that more severe NAFLD would be associated with the highest quartiles of uric acid.
RESULTS: Compared to the 1st quartile, the odds ratio for NAFLD was 1.79 (95% C.I. 1.49-2.15, p<0.001) and 3.14 (95% C.I. 2.63-3.75, p<0.001) for the 3rd and 4th quartiles, respectively. After adjusting for demographics, hypertension, waist circumference, triglycerides, high-density lipoprotein-cholesterol, homeostasis model assessment-estimated insulin resistance, estimated glomerular filtration rate, and aspartate aminotransferase, uric acid (4th quartile) was significantly associated with NAFLD (odds ratio 1.43; 95% C.I. 1.16-1.76, p<0.001). Positive parameter estimates suggest increasing uric acid is associated with greater severity of NAFLD.
CONCLUSIONS: Elevated uric acid level is independently associated with ultrasound-diagnosed NAFLD in a nationally representative sample of United States nondiabetic adults. Increasing uric acid is associated with increasing severity of NAFLD on ultrasonography. These findings warrant further studies on the role of uric acid in NAFLD.
Authors:
Jeffrey C Sirota; Kim McFann; Giovanni Targher; Richard J Johnson; Michel Chonchol; Diana I Jalal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  62     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-07-01     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aspartate Aminotransferases / blood
Cholesterol, HDL / blood
Cross-Sectional Studies
Fatty Liver / blood*,  ultrasonography*
Female
Humans
Insulin Resistance / physiology
Logistic Models
Male
Metabolic Syndrome X / blood,  ultrasonography
Middle Aged
Multivariate Analysis
Nutrition Surveys
Triglycerides / blood
United States
Uric Acid / blood*
Waist Circumference / physiology
Young Adult
Grant Support
ID/Acronym/Agency:
1K23DK088833/DK/NIDDK NIH HHS; K23 DK088833/DK/NIDDK NIH HHS; R01 DK081473/DK/NIDDK NIH HHS; R01 HL-68607/HL/NHLBI NIH HHS; R01 HL068607/HL/NHLBI NIH HHS; R01DK078112-01A2/DK/NIDDK NIH HHS; R01DK081473-01A1/DK/NIDDK NIH HHS; R03DK094484/DK/NIDDK NIH HHS; UL1 RR025780/RR/NCRR NIH HHS; UL1 RR025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides; 268B43MJ25/Uric Acid; EC 2.6.1.1/Aspartate Aminotransferases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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