| Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. | |
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MedLine Citation:
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PMID: 20458845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND STUDY AIMS: The question of whether elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease evident on ultrasonography was investigated by longitudinal approach in Japanese undergoing a health checkup. PATIENTS AND METHODS: A total of 1,386 male and 3,453 female nondrinkers participating in health checkups in both 2000 and 2005 were included. Multiple logistic regression analyses were performed for 1,042 men (51.4 +/- 11.2 years old) and 3,076 women (51.8 +/- 9.2 years old) to identify independent factors for newly developed nonalcoholic fatty liver disease in 2005. Adjustment was made for age, body mass index, body mass index increase for 5 years, systolic blood pressure, triglyceridemia, fasting blood glucose, and smoking. RESULTS: The prevalence of nonalcoholic fatty liver disease and body mass index, systolic blood pressure, and triglyceride were significantly higher in the participants with elevated serum uric acid, with a significant increasing trend in relation to serum uric acid quartiles. Nonalcoholic fatty liver disease was newly diagnosed in 17.4% of males and 8.2% of females, respectively, in 2005. Serum uric acid adjusted for other factors was a risk factor for nonalcoholic fatty liver disease in both sexes and quartiles 3 and 4 had significantly elevated risks. The odds ratio and 95% confidence interval for one increment of serum uric acid were 1.31 and 1.11-1.56 in men and 1.30 and 1.10-1.53 in women, respectively. CONCLUSIONS: Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. |
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Authors:
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Tamaki Yamada; Sadao Suzuki; Mitsuru Fukatsu; Tsuneya Wada; Takashi Yoshida; Takashi Joh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta gastro-enterologica Belgica Volume: 73 ISSN: 0001-5644 ISO Abbreviation: Acta Gastroenterol. Belg. Publication Date: 2010 Jan-Mar |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0414075 Medline TA: Acta Gastroenterol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 12-7 Citation Subset: IM |
Affiliation:
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Okazaki City Medical Association, Public Health Center, 1-9-1 Tatsumi-nishi, Okazaki, Aichi, Japan. t-yamada@okazaki-med.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking Asian Continental Ancestry Group / statistics & numerical data* Fatty Liver / blood*, epidemiology*, ultrasonography Female Humans Japan Longitudinal Studies Male Middle Aged Physical Examination Retrospective Studies Risk Factors Sex Factors Uric Acid / blood* |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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