Document Detail

Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup.
MedLine Citation:
PMID:  20458845     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND STUDY AIMS: The question of whether elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease evident on ultrasonography was investigated by longitudinal approach in Japanese undergoing a health checkup. PATIENTS AND METHODS: A total of 1,386 male and 3,453 female nondrinkers participating in health checkups in both 2000 and 2005 were included. Multiple logistic regression analyses were performed for 1,042 men (51.4 +/- 11.2 years old) and 3,076 women (51.8 +/- 9.2 years old) to identify independent factors for newly developed nonalcoholic fatty liver disease in 2005. Adjustment was made for age, body mass index, body mass index increase for 5 years, systolic blood pressure, triglyceridemia, fasting blood glucose, and smoking. RESULTS: The prevalence of nonalcoholic fatty liver disease and body mass index, systolic blood pressure, and triglyceride were significantly higher in the participants with elevated serum uric acid, with a significant increasing trend in relation to serum uric acid quartiles. Nonalcoholic fatty liver disease was newly diagnosed in 17.4% of males and 8.2% of females, respectively, in 2005. Serum uric acid adjusted for other factors was a risk factor for nonalcoholic fatty liver disease in both sexes and quartiles 3 and 4 had significantly elevated risks. The odds ratio and 95% confidence interval for one increment of serum uric acid were 1.31 and 1.11-1.56 in men and 1.30 and 1.10-1.53 in women, respectively. CONCLUSIONS: Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup.
Tamaki Yamada; Sadao Suzuki; Mitsuru Fukatsu; Tsuneya Wada; Takashi Yoshida; Takashi Joh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta gastro-enterologica Belgica     Volume:  73     ISSN:  0001-5644     ISO Abbreviation:  Acta Gastroenterol. Belg.     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2010-05-12     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0414075     Medline TA:  Acta Gastroenterol Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Okazaki City Medical Association, Public Health Center, 1-9-1 Tatsumi-nishi, Okazaki, Aichi, Japan.
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MeSH Terms
Alcohol Drinking
Asian Continental Ancestry Group / statistics & numerical data*
Fatty Liver / blood*,  epidemiology*,  ultrasonography
Longitudinal Studies
Middle Aged
Physical Examination
Retrospective Studies
Risk Factors
Sex Factors
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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