Document Detail

Elevated serum and synovial fluid TNF-like ligand 1A (TL1A) is associated with autoantibody production in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  23311967     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Tumour necrosis factor (TNF)-like ligand 1A (TL1A) is involved in rheumatoid arthritis (RA) but its clinical relevance in RA has not been fully elucidated. We analysed TL1A levels in the serum and synovial fluid (SF) of RA patients and investigated its clinical significance.
METHODS: TL1A levels were measured by enzyme-linked immunosorbent assay (ELISA) in 109 RA patients, 29 patients with osteoarthritis (OA), and 126 healthy controls. Anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor immunoglobulin G (RF-IgG) were tested by ELISA. RF-IgM, anti-keratin antibody (AKA), and anti-perinuclear factor (APF) antibodies, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and immunoglobulins were measured by standard laboratory techniques. The associations between TL1A and the clinical and serological features of RA were analysed.
RESULTS: TL1A concentrations were significantly elevated in both serum and SF of RA patients compared with OA patients and healthy controls. TL1A levels in RA SF were significantly higher than those in matched serum. A positive correlation was found between SF and serum TL1A levels. Serum TL1A concentrations were associated with RA-specific autoantibodies including RFs (RF-IgG, RF-IgM) and anti-citrullinated protein antibodies. Antibody production by peripheral blood mononuclear cells (PBMCs) from RA patients was elevated upon TL1A stimulation. However, there was no correlation between serum or SF TL1A levels and RA disease activity.
CONCLUSIONS: TL1A levels are significantly elevated in RA serum and SF and positively correlated with autoantibody production in RA, but failed as a disease activity marker. TL1A promotes antibody production by PBMCs from RA patients. The role of TL1A in the humoral autoimmune response may be important in the development of RA.
X Sun; J Zhao; R Liu; R Jia; L Sun; X Li; Z Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-14
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  42     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-05-16     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / blood,  immunology*
Autoantibodies / blood*
Autoantigens / immunology
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Leukocytes, Mononuclear / immunology
Middle Aged
Osteoarthritis / blood,  immunology*
Peptides, Cyclic / immunology*
Rheumatoid Factor / immunology*
Severity of Illness Index
Synovial Fluid / metabolism*
Tumor Necrosis Factor Ligand Superfamily Member 15 / blood*
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/Peptides, Cyclic; 0/Tumor Necrosis Factor Ligand Superfamily Member 15; 0/cyclic citrullinated peptide; 9009-79-4/Rheumatoid Factor
Comment In:
Scand J Rheumatol. 2014;43(2):175   [PMID:  24559200 ]
Scand J Rheumatol. 2014;43(2):176   [PMID:  24588514 ]

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