| Elevated serum parathormone levels are associated with myocardial iron overload in patients with beta-thalassaemia major. | |
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MedLine Citation:
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PMID: 19744128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with beta-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major. METHODS: In 62 patients (29 M and 33 F, mean age: 22.79 +/- 6.18 yr) with beta-thalassaemia major levels of intact parathormone (iPTH) and vitamin D metabolites [25(OmicronH)D(3) and 1,25(OmicronH)(2)D(3)] were measured in serum. Additionally, estimation of myocardial iron content was performed by magnetic resonance imaging, whereas mean serum ferritin concentrations were calculated for 1 yr prior to the study. RESULTS: Results showed markedly decreased levels of serum 25(OH)D(3) in 37 patients (60%), whereas 7 patients (11%) had borderline 25(OH)D(3) levels (between 50 and 75 nmol/L). Serum iPTH levels were significantly higher in patients having increased myocardial iron compared to those having normal myocardial iron (44.04 +/- 22.09 pg/mL vs. 31.39 +/- 14.30 pg/mL, P = 0.017). Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron. |
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Authors:
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Meropi Dimitriadou; Athanasios Christoforidis; Marina Economou; Ioanna Tsatra; Efthimia Vlachaki; Liana Fidani; George Katzos; Miranda Athanassiou-Metaxa |
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Publication Detail:
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Type: Journal Article Date: 2009-09-10 |
Journal Detail:
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Title: European journal of haematology Volume: 84 ISSN: 1600-0609 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 64-71 Citation Subset: IM |
Affiliation:
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1st Paediatric Department, Aristotle University of Thessaloniki, Greece. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Transfusion / adverse effects* Calcifediol / blood Calcitriol / blood Child Female Ferritins / blood Humans Iron / analysis*, blood Iron Overload / etiology*, pathology Magnetic Resonance Imaging Male Myocardium / chemistry*, pathology Parathyroid Hormone / blood* Vitamin D Deficiency / blood, etiology* Young Adult beta-Thalassemia / blood, pathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 19356-17-3/Calcifediol; 32222-06-3/Calcitriol; 7439-89-6/Iron; 9007-73-2/Ferritins |
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