Document Detail

Elevated serum parathormone levels are associated with myocardial iron overload in patients with beta-thalassaemia major.
MedLine Citation:
PMID:  19744128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Despite advances in conventional treatment, iron-induced cardiomyopathy is still the most frequent cause of death among patients with beta-thalassaemia major. Recent studies have correlated increased myocardial iron content to decreased levels of vitamin D in thalassaemic patients. The aim of this study was to measure parathormone (PTH) and metabolites of vitamin D and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major. METHODS: In 62 patients (29 M and 33 F, mean age: 22.79 +/- 6.18 yr) with beta-thalassaemia major levels of intact parathormone (iPTH) and vitamin D metabolites [25(OmicronH)D(3) and 1,25(OmicronH)(2)D(3)] were measured in serum. Additionally, estimation of myocardial iron content was performed by magnetic resonance imaging, whereas mean serum ferritin concentrations were calculated for 1 yr prior to the study. RESULTS: Results showed markedly decreased levels of serum 25(OH)D(3) in 37 patients (60%), whereas 7 patients (11%) had borderline 25(OH)D(3) levels (between 50 and 75 nmol/L). Serum iPTH levels were significantly higher in patients having increased myocardial iron compared to those having normal myocardial iron (44.04 +/- 22.09 pg/mL vs. 31.39 +/- 14.30 pg/mL, P = 0.017). Multivariant regression analysis identified PTH levels as the major predictor of increased myocardial iron.
Meropi Dimitriadou; Athanasios Christoforidis; Marina Economou; Ioanna Tsatra; Efthimia Vlachaki; Liana Fidani; George Katzos; Miranda Athanassiou-Metaxa
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Publication Detail:
Type:  Journal Article     Date:  2009-09-10
Journal Detail:
Title:  European journal of haematology     Volume:  84     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-71     Citation Subset:  IM    
1st Paediatric Department, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Blood Transfusion / adverse effects*
Calcifediol / blood
Calcitriol / blood
Ferritins / blood
Iron / analysis*,  blood
Iron Overload / etiology*,  pathology
Magnetic Resonance Imaging
Myocardium / chemistry*,  pathology
Parathyroid Hormone / blood*
Vitamin D Deficiency / blood,  etiology*
Young Adult
beta-Thalassemia / blood,  pathology,  therapy*
Reg. No./Substance:
0/Parathyroid Hormone; 19356-17-3/Calcifediol; 32222-06-3/Calcitriol; 7439-89-6/Iron; 9007-73-2/Ferritins

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