Document Detail

Elevated serum lipoprotein(a) level is an independent marker of severity of thoracic aortic atherosclerosis.
MedLine Citation:
PMID:  12006448     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Lipoprotein(a) (Lp[a]) level is a risk factor for ischemic heart disease, cerebrovascular disease, and peripheral vascular disease. However, few data are available concerning the relationship between Lp(a) level and severity of thoracic aortic atherosclerosis. We hypothesized in this transesophageal echocardiography (TEE) study that Lp(a) level is a marker of severity of thoracic aortic atherosclerosis. DESIGN: Cross-sectional study. SETTING: University hospital. PATIENTS: Risk factors, coronary angiographic features, and TEE findings were analyzed prospectively in 119 patients with valvular disease. MEASUREMENTS AND RESULTS: The following risk factors were recorded: age, gender, hypertension, smoking, lipid parameters, diabetes, body mass index, and family history of coronary artery disease. Serum levels of Lp(a) were measured for each patient. By univariate analysis, age, diabetes, hypertension, smoking, Lp(a), total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were significant predictors of thoracic aortic atherosclerosis. There was a positive and significant correlation between the Lp(a) levels and the score of severity of thoracic aortic atherosclerosis (p = 0.0001). Multivariate regression analysis revealed that Lp(a) was an independent predictor of severity of thoracic aortic atherosclerosis (p = 0.0001). CONCLUSION: This prospective study indicates that serum Lp(a) level is an independent marker of severity of thoracic aortic atherosclerosis detected by multiplane TEE. These findings emphasize the role of Lp(a) as a marker of atherosclerotic lesions in the major arterial locations.
Marcel Peltier; Michèle C Iannetta Peltier; Maurice E Sarano; Jean-Philippe M Lesbre; Jean-Laurent Colas; Christophe M Tribouilloy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  121     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-13     Completed Date:  2002-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1589-94     Citation Subset:  AIM; IM    
Department of Cardiology, South Hospital, Amiens, France.
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MeSH Terms
Aged, 80 and over
Aorta, Thoracic / ultrasonography
Aortic Diseases / blood,  complications,  diagnosis*,  ultrasonography
Arteriosclerosis / blood,  diagnosis*,  ultrasonography
Biological Markers / blood
Coronary Angiography
Coronary Artery Disease / complications,  radiography
Echocardiography, Transesophageal
Lipoprotein(a) / blood*
Middle Aged
Multivariate Analysis
Prospective Studies
Regression Analysis
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Lipoprotein(a)

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