| Elevated serum lipoprotein(a) level is an independent marker of severity of thoracic aortic atherosclerosis. | |
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MedLine Citation:
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PMID: 12006448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: Lipoprotein(a) (Lp[a]) level is a risk factor for ischemic heart disease, cerebrovascular disease, and peripheral vascular disease. However, few data are available concerning the relationship between Lp(a) level and severity of thoracic aortic atherosclerosis. We hypothesized in this transesophageal echocardiography (TEE) study that Lp(a) level is a marker of severity of thoracic aortic atherosclerosis. DESIGN: Cross-sectional study. SETTING: University hospital. PATIENTS: Risk factors, coronary angiographic features, and TEE findings were analyzed prospectively in 119 patients with valvular disease. MEASUREMENTS AND RESULTS: The following risk factors were recorded: age, gender, hypertension, smoking, lipid parameters, diabetes, body mass index, and family history of coronary artery disease. Serum levels of Lp(a) were measured for each patient. By univariate analysis, age, diabetes, hypertension, smoking, Lp(a), total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were significant predictors of thoracic aortic atherosclerosis. There was a positive and significant correlation between the Lp(a) levels and the score of severity of thoracic aortic atherosclerosis (p = 0.0001). Multivariate regression analysis revealed that Lp(a) was an independent predictor of severity of thoracic aortic atherosclerosis (p = 0.0001). CONCLUSION: This prospective study indicates that serum Lp(a) level is an independent marker of severity of thoracic aortic atherosclerosis detected by multiplane TEE. These findings emphasize the role of Lp(a) as a marker of atherosclerotic lesions in the major arterial locations. |
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Authors:
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Marcel Peltier; Michèle C Iannetta Peltier; Maurice E Sarano; Jean-Philippe M Lesbre; Jean-Laurent Colas; Christophe M Tribouilloy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 121 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-13 Completed Date: 2002-06-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1589-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, South Hospital, Amiens, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aorta, Thoracic / ultrasonography Aortic Diseases / blood, complications, diagnosis*, ultrasonography Arteriosclerosis / blood, diagnosis*, ultrasonography Biological Markers / blood Coronary Angiography Coronary Artery Disease / complications, radiography Echocardiography, Transesophageal Female Humans Lipoprotein(a) / blood* Male Middle Aged Multivariate Analysis Prospective Studies Regression Analysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipoprotein(a) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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