Document Detail

Elevated serum lipids in veterans with combat-related chronic posttraumatic stress disorder.
MedLine Citation:
PMID:  12476477     Owner:  NLM     Status:  MEDLINE    
AIM: To assess possible differences in serum cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, arteriosclerosis index, established risk factor (ERF) of arteriosclerosis, and 10-year risk for coronary disease according to the Adult Treatment Panel III (ATP-III) between veterans with combat-related posttraumatic stress disorder (PTSD) and a control group consisting of patients with major depressive disorder. METHOD: We determined serum cholesterol, LDL-C, HDL-C, and triglycerides in the patients with PTSD (n = 103) and patients with major depressive disorder (n = 92), using the enzyme-assay method. AI, ERF, and ATP-III were calculated from cholesterol, LDL-C, and HDL-C levels. The groups were matched in age and body mass index (BMI). Patients with major depressive disorder were chosen as a control group because they do not have changes in serum lipids. RESULTS: Patients with combat-related PTSD had higher mean concentration of cholesterol (6.2+/-1.1 mmol/L vs 5.3+/-0.9 mmol/L; p<0.001), LDL-C (3.9+/-0.7 mmol/L vs 3.5+/-1.0 mmol/L; p = 0.005), and triglycerides (2.9+/-2.3 mmol/L vs 1.5+/-0.5 mmol/L; p<0.001), and lower HDL-C (1.0+/-0.3 mmol/L vs 1.3+/-0.2 mmol/L; p<0.001) than the control group. Arteriosclerosis index (4.2+/-1.2 vs 3.7+/-1.7; p = 0.050), ERF (6.4+/-1.9 vs 5.5+/-2.4; p = 0.010), and ATP-III (12.1+/-3.3 vs 10.2+/-3.8; p<0.001) were higher in PTSD than in the control group. CONCLUSION: Elevated concentrations of serum lipids are associated with combat-related PTSD. This may imply that patients with combat-related PTSD are under a higher risk for arteriosclerosis.
Vlasta Solter; Vlatko Thaller; Dalibor Karlović; Danijel Crnković
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Croatian medical journal     Volume:  43     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  685-9     Citation Subset:  IM    
University Department of Psychiatry, Sisters of Mercy University Hospital, Zagreb, Croatia.
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MeSH Terms
Arteriosclerosis / epidemiology
Case-Control Studies
Cholesterol, HDL / blood*
Cholesterol, LDL / blood*
Combat Disorders / blood*,  complications
Coronary Artery Disease / complications,  epidemiology
Depressive Disorder, Major / blood,  complications
Hospitals, University
Hypercholesterolemia / complications
Hypertriglyceridemia / complications
Risk Factors
Stress Disorders, Post-Traumatic / blood*,  complications
Triglycerides / blood*
Veterans / psychology*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides

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