Document Detail


Elevated serum levels of Vitamin D in infants with urolithiasis.
MedLine Citation:
PMID:  22555482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The pathophysiology of urolithiasis in infancy is not well known. The aim of this study was to investigate whether infants with urolithiasis have higher serum levels of vitamin D, as a possible risk factor for urolithiasis, compared to infants without urinary calculi.
MATERIALS AND METHODS: In this case-control study, 36 infants with urolithiasis (age range, 2.5 to 24 months) were enrolled as well as 36 age- and sex-matched infants without urolithiasis. Random urine samples were tested for calcium, phosphorous, oxalate, citrate, uric acid, sodium, potassium, magnesium, and creatinine levels, and also nitroprusside test was done on the samples. Serum levels of potassium, urea nitrogen, creatinine, 25-hydroxyvitamin D3, parathyroid hormone, calcium, phosphorous, and uric acid were measured in all of the infants with urolithiasis. Serum levels of 25-hydroxyvitamin D3 were also measured in the control group.
RESULTS: Serum levels of 25-hydroxyvitamin D3 were significantly higher in the infants with urolithiasis than in the controls (33.85 ± 14.78 ng/mL versus 18.26 ± 7.43 ng/mL, P < .001). Nine infants in the urolithiasis group (25%) were found to have hypercalcemia; 3 of these cases also had hypervitaminosis D. Hypercalciuria was detected in 10 infants with urolithiasis (27.8%), hypocitraturia in 6 (16.7%), hypomagnesiuria in 3 (8.3%), and hyperoxaluria in 1 (2.8%). Nineteen infants with urolithiasis had at least one metabolic disorder.
CONCLUSIONS: High serum levels of vitamin D may play an important role in the pathogenesis of urolithiasis in infants with hypercalcemia. We recommend evaluation of vitamin D levels in these infants.
Authors:
Mohammad Hossein Fallahzadeh; Javad Zare; Ghamar Hosseini Al-Hashemi; Ali Derakhshan; Mitra Basiratnia; Mohammad Mehdi Arasteh; Mohammad Amin Fallahzadeh; Mohammad Kazem Fallahzadeh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  6     ISSN:  1735-8604     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-07-16     Revised Date:  2012-11-08    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Affiliation:
Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism
Calcifediol / metabolism*
Case-Control Studies
Female
Humans
Infant
Kidney Calculi / blood*,  etiology,  urine
Male
Risk Factors
Sunlight
Vitamin D / administration & dosage
Vitamins / administration & dosage
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Vitamins; 1406-16-2/Vitamin D; 19356-17-3/Calcifediol
Comments/Corrections
Comment In:
Iran J Kidney Dis. 2012 Sep;6(5):391-2   [PMID:  22976269 ]

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