| Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis. | |
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MedLine Citation:
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PMID: 9236675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined serum concentrations of neopterin, soluble tumour necrosis factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor (sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis (DM), including 15 patients with primary PM, 13 patients with primary DM, and 16 patients with myositis and systemic sclerosis in overlap. Concentrations of neopterin, sTNF-R and sIL-2R were measured using commercially available immunoassays. Serum neopterin was increased in 35 of 44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%) patients, respectively. There were significant correlations between serum neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P < 0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with clinical (neuromuscular and activities of daily living scores) and laboratory (creatine kinase levels) manifestations of myositis. Increased serum levels of neopterin were associated with non-muscular manifestations of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory marker for ongoing immune activation and global disease activity in PM/DM. |
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Authors:
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M Y Samsonov; E L Nassonov; G P Tilz; B M Geht; U Demel; G T Gurkina; V Z Shtutman; A G Guseva; H Wachter; D Fuchs |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 36 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-25 Completed Date: 1997-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 656-60 Citation Subset: AIM; IM |
Affiliation:
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Cardiology Research Centre, Moscow, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Markers Biopterin / analogs & derivatives*, blood Dermatomyositis / blood* Female Humans Male Middle Aged Neopterin Polymyositis / blood* Receptors, Interleukin-2 / blood Receptors, Tumor Necrosis Factor / blood Solubility |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Receptors, Interleukin-2; 0/Receptors, Tumor Necrosis Factor; 22150-76-1/Biopterin; 670-65-5/Neopterin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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