Document Detail


Elevated serum levels of neopterin in adult patients with polymyositis/dermatomyositis.
MedLine Citation:
PMID:  9236675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined serum concentrations of neopterin, soluble tumour necrosis factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor (sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis (DM), including 15 patients with primary PM, 13 patients with primary DM, and 16 patients with myositis and systemic sclerosis in overlap. Concentrations of neopterin, sTNF-R and sIL-2R were measured using commercially available immunoassays. Serum neopterin was increased in 35 of 44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%) patients, respectively. There were significant correlations between serum neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P < 0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with clinical (neuromuscular and activities of daily living scores) and laboratory (creatine kinase levels) manifestations of myositis. Increased serum levels of neopterin were associated with non-muscular manifestations of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory marker for ongoing immune activation and global disease activity in PM/DM.
Authors:
M Y Samsonov; E L Nassonov; G P Tilz; B M Geht; U Demel; G T Gurkina; V Z Shtutman; A G Guseva; H Wachter; D Fuchs
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  36     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-25     Completed Date:  1997-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  656-60     Citation Subset:  AIM; IM    
Affiliation:
Cardiology Research Centre, Moscow, Russia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biological Markers
Biopterin / analogs & derivatives*,  blood
Dermatomyositis / blood*
Female
Humans
Male
Middle Aged
Neopterin
Polymyositis / blood*
Receptors, Interleukin-2 / blood
Receptors, Tumor Necrosis Factor / blood
Solubility
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Interleukin-2; 0/Receptors, Tumor Necrosis Factor; 22150-76-1/Biopterin; 670-65-5/Neopterin

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