| Elevated serum levels of the c-erbB-2 encoded oncoprotein fragment in cases of pure preeclampsia and HELLP syndrome. | |
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MedLine Citation:
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PMID: 9158311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: During normal human ontogenesis an overexpression of the c-erbB-2 encoded oncoprotein p185 (HER2/neu) occurs in the placenta and on fetal epithelial cells. It is accompanied by the increase of a 105 kD fragment (p105) in both maternal serum and cord blood. We examined whether p105 levels in maternal serum are influenced by destructions of placental tissue, fetal growth disturbances and placental circulation disorders. METHODS: We analysed p105 serum concentrations in patients with abortion (n = 25), ectopic pregnancy (n = 5), intrauterine growth retardation (n = 9), pregnancy induced hypertension (n = 24) and compared them with normal pregnancies of a corresponding gestational age. RESULTS: Patients with abortions showed normal p105 values. Intrauterine growth retardation was associated with lower p105 levels (p < 0.05) whereas patients with pure preeclampsia (p < 0.001) and HELLP syndrome (p < 0.05) had significantly higher levels. CONCLUSION: The elevation of p105 in sera of preeclamptic women could be due to an increased fetomaternal transfer of p105. |
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Authors:
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H Meden; S Mielke; W Wuttke; W Kuhn |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 23 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-12 Completed Date: 1997-06-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 213-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Göttingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Missed
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blood Abortion, Threatened / blood Female Fetal Growth Retardation / blood HELLP Syndrome / blood* Humans Hypertension / blood Pre-Eclampsia / blood* Pregnancy Pregnancy Complications, Cardiovascular / blood Pregnancy, Ectopic / blood Receptor, erbB-2 / blood* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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