| Elevated serum chromogranin A in patients with hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 12447608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromogranin A is a cellular marker forneuroendocrine tumors. Elevated levels of chromogranin A are also found in patients with cancers of epithelial origin when neuroendocrine differentiation occurs, which is associated with a poor prognosis. We investigated the prevalence of serum levels of chromogranin A in patients with primary liver cancer. Seventy-nine patients (65 males, mean age 67.6 years, range 48-88 years) with liver cirrhosis and hepatocellular carcinoma were studied. The etiology of cirrhosis was identified as due to hepatitis C virus infection in 47 patients, to hepatitis C virus and alcohol in 7, to alcohol alone in 14, to hepatitis C and B virus in 2, and to hepatitis B virus alone in 4. Of the remaining patients, 2 suffered from hemochromatosis and 3 had cryptogenic cirrhosis. According to the Child-Pugh's score, 54 patients belonged to class A, 22 to class B, and 3 to class C. The concentration of chromogranin A was measured in serum with a commercial solid-phase two-site immunoradiometric assay. Elevated serum levels of chromogranin A were found in 32 of 79 patients (43%). Levels over 600 ng/ml were present in 7 of 76 patients (9.2%), all of whom had very high serum levels of alpha-fetoprotein. Hence, elevated serum levels of chromogranin A are present in over one third of patients with hepatocellular carcinoma. It is therefore possible that some hepatocellular carcinomas could acquire a neuroendocrine differentiation. We propose further studies to ascertain whether serum levels of chromogranin A are useful as a prognostic marker for hepatocellular carcinoma as in prostate cancer. |
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Authors:
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N Leone; R Pellicano; F Brunello; M Rizzetto; A Ponzetto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental medicine Volume: 2 ISSN: 1591-8890 ISO Abbreviation: Clin. Exp. Med. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-05-27 Revised Date: 2007-04-17 |
Medline Journal Info:
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Nlm Unique ID: 100973405 Medline TA: Clin Exp Med Country: Italy |
Other Details:
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Languages: eng Pagination: 119-23 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hospital S Giovanni Battista, Turin, Italy. leone.nic@tiscalinet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Carcinoma, Hepatocellular / blood*, pathology Cell Differentiation Chromogranin A Chromogranins / blood* Female Humans Liver Neoplasms / blood*, pathology Male Middle Aged Neuroendocrine Tumors / blood, pathology Prognosis Tumor Markers, Biological / blood alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/CHGA protein, human; 0/Chromogranin A; 0/Chromogranins; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins |
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