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Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes.
MedLine Citation:
PMID:  22783586     Owner:  NLM     Status:  In-Process    
BACKGROUND: Coronary artery disease (CAD) is a major vascular complication of type 2 diabetes mellitus (T2DM) and reveals high mortality. Serum levels of chemerin have been suggested to be involved in glucose and lipid metabolism and associated with several cardiovascular factors. The aim of this study is to investigate the association of serum chemerin levels with the presence of CAD in patients with T2DM.
METHODS: Serum levels of chemerin were determined in 286 patients with T2DM who underwent coronary angiography for the evaluation of CAD and 128 healthy subjects. The T2DM patients group included 150 patients with CAD and 136 patients without CAD.
RESULTS: Serum chemerin levels were significantly higher in T2DM patients with CAD compared with those without CAD and healthy controls. However, there was no significant difference in the levels of serum chemerin between T2DM patients without CAD and healthy controls. Multivariable logistic regression analysis revealed that serum chemerin levels were an independent determinant of the presence of CAD in patients with T2DM (OR 1.057, 95% CI 1.040 to 1.075; p < 0.001). In addition, linear regression analysis showed that serum chemerin levels were positively correlated with body mass index, systolic blood pressure, homeostasis model assessment of insulin resistance, and serum triglycerides.
CONCLUSIONS: There is an independent association between serum levels of chemerin and the presence of CAD in patients with T2DM.
Xiaohong Lin; Xiangyu Tang; Qiong Jiang; Qing Liu; Zhang Lin; Junhua Lin; Lianglong Chen; Huashan Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical laboratory     Volume:  58     ISSN:  1433-6510     ISO Abbreviation:  Clin. Lab.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705611     Medline TA:  Clin Lab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
Fujian Institute of Coronary Artery Disease, Fujian Medical University, Fuzhou, PR China.
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