Document Detail


Elevated serum cardiac markers predict coronary artery disease in patients with a history of heart failure who present with chest pain: insights from the i*trACS registry.
MedLine Citation:
PMID:  17541309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The significance of a history of heart failure (HF) in patients presenting with acute coronary syndromes and elevated cardiac markers is unclear. The authors performed an analysis of patients enrolled in the Internet Tracking Registry of Acute Coronary Syndromes (i*trACS). Cardiac marker measurement and cardiac catheterization were performed in 1174 patients. Of these, 116 (9.9%) had heart failure (HF). Coronary artery disease (CAD) was found in 61 (52.6%) patients in the HF group and 581 (54.9%) in the group without HF. In the non-HF cohort, positive markers occurred in 306 patients, in whom 217 (70.9%) had CAD at catheterization. In the HF subset, 24 patients had positive biomarkers and 15 (62.5%) had CAD. A history of HF did not lessen the likelihood of CAD as evidenced by angiography and does not diminish the utility of cardiac markers in diagnosing acute coronary syndromes.
Authors:
Jonathan Glauser; James Erickson; Deepak Bhatt; Christopher Lindsell; Brian Gibler; James Hoekstra; Charles Pollack; Judd Hollander; W Franklin Peacock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congestive heart failure (Greenwich, Conn.)     Volume:  13     ISSN:  1527-5299     ISO Abbreviation:  Congest Heart Fail     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-01     Completed Date:  2007-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9714174     Medline TA:  Congest Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Affiliation:
Division of Medicine, Department of Emergency Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. glausej@ccf.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / blood*
Biological Markers / blood
Case-Control Studies
Coronary Artery Disease / blood*
Coronary Stenosis / blood
Creatine Kinase, MB Form / blood*
Female
Heart Catheterization
Heart Failure / blood*
Humans
Internet
Male
Middle Aged
Predictive Value of Tests
Registries
Research Design
Troponin I / blood*
Troponin T / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin I; 0/Troponin T; EC 2.7.3.2/Creatine Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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