Document Detail


Elevated serum cancer antigen 125 levels in advanced abdominal tuberculosis.
MedLine Citation:
PMID:  11918456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 48-yr-old female presented with a 1-yr history of pain in the hypochondrium and epigastrium. All routine investigations and computed tomography (CT) of the abdomen were done. CT findings revealed a well-defined cystic mass in the right ovary, and ascitis with features suggestive of secondaries over the omentum and peritoneal surface. The serum CA125 was 1255 U/mL (normal range 0-35 U/mL), which was indicative of ovarian malignancy. An exploratory laparotomy was performed. Histopathological examination of organs revealed the presence of granuloma. The patient was advised to undergo antitubercular treatment (ATT) and follow-up every month. After 1 mo of ATT, the CA125 level came down to 42 U/mL, which was near normal. As tuberculosis requires only a conservative management, we suggest that in cases of abdominopelvic mass with or without ascitis, high serum CA125 should always raise a suspicion of tuberculosis and a laparoscopy combined with peritoneal biopsy should be performed to confirm the diagnosis. This will prevent unnecessary laparotomies. Moreover, serum CA125 can be used to monitor the response of disease to antitubercular treatment.
Authors:
V Thakur; U Mukherjee; K Kumar
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  18     ISSN:  1357-0560     ISO Abbreviation:  Med. Oncol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-91     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Batra Hospital and Medical Research Centre, New Delhi, India. vthakur57@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adnexal Diseases / blood*,  diagnosis*
Ascites
CA-125 Antigen / blood*
Diagnosis, Differential
Female
Humans
Middle Aged
Ovarian Neoplasms / diagnosis*
Peritonitis, Tuberculous / blood,  diagnosis*
Tuberculoma / blood,  diagnosis*
Tuberculosis, Female Genital / blood*,  diagnosis*
Chemical
Reg. No./Substance:
0/CA-125 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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