| Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. | |
| | |
MedLine Citation:
|
PMID: 11122088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of cytokines in the development of acute chest syndrome (ACS) in patients with sickle cell disease (SCD) was studied. Serum interleukin 8 (IL-8) levels were elevated in 14 episodes and undetectable in six out of 20 episodes of ACS in 19 patients with SCD. In contrast, IL-8 levels were undetectable in the sera of 29 control patients with SCD studied during routine clinic visits or hospitalization for vaso-occlusive crises. The differences in mean IL-8 levels and the proportion of patients with detectable levels between the two groups were highly significant (P < 0.0001 and 0.04 respectively). The mean IL-8 level in bronchial fluid samples from children with ACS was also significantly higher than that in sickle cell patients undergoing elective surgery (5500 +/- 1400 pg/ml vs. 1900 +/- 470 pg/ml, P = 0.03). Granulocyte colony-stimulating factor (G-CSF) (2000 +/- 1700 pg/ml) was present in five out of six samples of bronchial fluid, but not serum, from children with ACS. All but one of the patients with ACS studied were negative for the Duffy red cell antigen, which is a receptor that binds and inactivates IL-8 and other chemokines. These findings suggest that IL-8 and G-CSF may play a role in the development of the ACS and the complications associated with it. |
| | |
Authors:
|
M R Abboud; E C Taylor; D Habib; T Dantzler-Johnson; S M Jackson; F Xu; J Laver; S K Ballas |
Related Documents
:
|
7296148 - Dupuytren's disease and the sickle-cell trait in a female black patient. 15916058 - Case report post-splenectomy sepsis in thalassemic patients. 19487178 - Evolution of hematological parameters in hiv-1-infected patients with and without thala... 8177388 - Management of neurosurgical patients with hyponatremia and natriuresis. 15491038 - Ocular surface disorders and tear function changes in patients with chronic renal failure. 22911528 - Body composition and serum levels of adiponectin, vascular endothelial growth factor, a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of haematology Volume: 111 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2001-01-08 Completed Date: 2001-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 482-90 Citation Subset: IM |
Affiliation:
|
Division of Pediatric Hematology/Oncology at the Medical University of South Carolina, Charleston, SC 29425-3311, USA. abboudm@musc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adolescent Adult Bronchoalveolar Lavage Fluid / immunology* Case-Control Studies Chest Pain / immunology* Child Child, Preschool Cytokines / blood* Duffy Blood-Group System Female Granulocyte Colony-Stimulating Factor / blood Humans Interleukin-8 / analysis, genetics Male Pleural Effusion / immunology* Polymerase Chain Reaction RNA, Messenger / analysis Sickle Cell Trait / blood, immunology* Syndrome |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Duffy Blood-Group System; 0/Interleukin-8; 0/RNA, Messenger; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet and leucocyte activation in childhood sickle cell disease: association with nocturnal hypox...
Next Document: Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be ...