| Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt-Koyanagi-Harada disease. | |
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MedLine Citation:
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PMID: 19910285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Patients with Vogt-Koyanagi-Harada (VKH) disease are known to have severe inflammation after cataract surgery. This study was designed to investigate the role of IL-17-producing T helper (Th17) cell-related pro-inflammatory cytokines on postoperative inflammation in VKH patients. METHODS: Serum from nine VKH patients and nine controls with age-related or congenital cataract was collected before and 1, 7, 30 and 90 days after surgery, and aqueous humor (AqH) at the commencement of surgery. Protein levels of IL-23, IL-27, IL-17 and IFN-gamma in serum and AqH were measured by ELISA. A laser flare-cell photometer was used to quantify intraocular inflammation. RESULTS: Serum IL-23 levels were significantly increased in VKH compared with control patients and peaked at 1 day postoperative, decreased rapidly in the first week, then attenuated gradually. In VKH patients, serum levels of IFN-gamma were elevated in the first week after surgery and IL-27 was upregulated in the first month. Importantly, serum IL-23 levels were strongly correlated with aqueous flare value (r=0.689; p=0.007) and cell counts (r=0.671; p=0.01) in VKH compared with control patients. CONCLUSIONS: The data indicate that serum IL-23 levels are significantly elevated in VKH compared with control patients and are strongly associated with postoperative intraocular inflammation. |
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Authors:
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Shuhong Jiang; Xialin Liu; Lixia Luo; Bo Qu; Xiangkun Huang; Li Xu; Ying Lin; Shaobi Ye; Yizhi Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-11 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 94 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 1078-82 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aqueous Humor / immunology Cataract / etiology Cytokines / blood Female Humans Interleukin-23 / blood* Male Middle Aged Panuveitis / etiology*, immunology Phacoemulsification / adverse effects* Uveomeningoencephalitic Syndrome / complications, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-23 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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