| Elevated serum CA-125 levels in patients with non-tuberculous mycobacterial lung disease. | |
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MedLine Citation:
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PMID: 20070585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical significance of serum CA-125 measurements in patients with non-tuberculous mycobacterial (NTM) lung disease has not been investigated. This study showed that serum CA-125 levels were elevated in some patients with NTM pulmonary disease. Further studies are needed to investigate the usefulness of serum CA-125 measurements in patients with NTM pulmonary disease. BACKGROUND AND OBJECTIVE: Although cancer antigen 125 (CA-125) is a useful marker for the diagnosis of ovarian cancer, CA-125 levels are elevated in many benign conditions, including tuberculosis (TB). The clinical significance of serum CA-125 measurements in patients with non-tuberculous mycobacterial (NTM) lung disease was evaluated. METHODS: Patients with NTM lung disease (n=53), in whom serum CA-125 levels had been measured, were retrospectively enrolled in the study. Twenty-eight patients with pulmonary TB were included as a comparison group. Clinical, radiological and bacteriological parameters were assessed according to serum CA-125 status. RESULTS: Among 53 patients with NTM lung disease, serum CA-125 levels were elevated in 28 (52.8%), and this proportion was not significantly different from that of the TB patients (44.8%). Cavitation and upper lobe cavitary type disease were more frequent in NTM patients with elevated serum CA-125 levels compared with those without increased CA-125 levels (P<0.05 for both). The clinical course of NTM lung disease was correlated with changes in serum CA-125 levels. CONCLUSIONS: Serum CA-125 levels were increased in significant proportions of NTM patients, as well as TB patients. Further studies are needed to investigate the usefulness of serum CA-125 measurements in patients with NTM pulmonary disease. |
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Authors:
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Sun Young Kim; Yoonki Hong; Chang-Min Choi; Yeon-Mok Oh; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Tae Sun Shim |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-01-11 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: 15 ISSN: 1440-1843 ISO Abbreviation: Respirology Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: Australia |
Other Details:
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Languages: eng Pagination: 357-60 Citation Subset: IM |
Affiliation:
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Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood CA-125 Antigen / blood* Disease Progression Female Humans Korea Lung / microbiology Lung Diseases / blood*, microbiology* Male Middle Aged Mycobacterium avium Complex / isolation & purification Mycobacterium avium-intracellulare Infection / blood*, microbiology* Retrospective Studies Tuberculosis, Pulmonary / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CA-125 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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