Document Detail


Elevated serum CA-125 levels in patients with non-tuberculous mycobacterial lung disease.
MedLine Citation:
PMID:  20070585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical significance of serum CA-125 measurements in patients with non-tuberculous mycobacterial (NTM) lung disease has not been investigated. This study showed that serum CA-125 levels were elevated in some patients with NTM pulmonary disease. Further studies are needed to investigate the usefulness of serum CA-125 measurements in patients with NTM pulmonary disease. BACKGROUND AND OBJECTIVE: Although cancer antigen 125 (CA-125) is a useful marker for the diagnosis of ovarian cancer, CA-125 levels are elevated in many benign conditions, including tuberculosis (TB). The clinical significance of serum CA-125 measurements in patients with non-tuberculous mycobacterial (NTM) lung disease was evaluated. METHODS: Patients with NTM lung disease (n=53), in whom serum CA-125 levels had been measured, were retrospectively enrolled in the study. Twenty-eight patients with pulmonary TB were included as a comparison group. Clinical, radiological and bacteriological parameters were assessed according to serum CA-125 status. RESULTS: Among 53 patients with NTM lung disease, serum CA-125 levels were elevated in 28 (52.8%), and this proportion was not significantly different from that of the TB patients (44.8%). Cavitation and upper lobe cavitary type disease were more frequent in NTM patients with elevated serum CA-125 levels compared with those without increased CA-125 levels (P<0.05 for both). The clinical course of NTM lung disease was correlated with changes in serum CA-125 levels. CONCLUSIONS: Serum CA-125 levels were increased in significant proportions of NTM patients, as well as TB patients. Further studies are needed to investigate the usefulness of serum CA-125 measurements in patients with NTM pulmonary disease.
Authors:
Sun Young Kim; Yoonki Hong; Chang-Min Choi; Yeon-Mok Oh; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Tae Sun Shim
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-01-11
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
Affiliation:
Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
CA-125 Antigen / blood*
Disease Progression
Female
Humans
Korea
Lung / microbiology
Lung Diseases / blood*,  microbiology*
Male
Middle Aged
Mycobacterium avium Complex / isolation & purification
Mycobacterium avium-intracellulare Infection / blood*,  microbiology*
Retrospective Studies
Tuberculosis, Pulmonary / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CA-125 Antigen

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