| Elevated serum CA 125 levels in mitral stenotic patients with heart failure. | |
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MedLine Citation:
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PMID: 12975539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elevated tumor marker levels have been reported in heart failure patients with left ventricular (LV) systolic dysfunction and enlargement. The levels of several tumor markers, including CA 125, CA 19-9, CA 15-3 and CEA, in rheumatic mitral stenotic patients were compared to the control group. MATERIALS AND METHODS: Tumor markers were measured in 60 mitral stenotic patients and in 30 normal subjects who served as the control group. Mitral stenotic patients were classified into two categories of cardiac dysfunction based on the classification of the New York Heart Association (NYHA). Group I consisted of 31 patients in NYHA class 3-4 and group II of 29 patients in NYHA class 1-2. Echocardiographic examinations and invasive hemodynamic monitoring were performed in all patients. RESULTS: Group I patients had decreased mitral valve area (p = 0.004) and higher left atrial diameter (p = 0.003) than group II patients. Right atrial, mean pulmonary artery and pulmonary capillary wedge pressures and transmitral gradient were higher in group I than in group II (p = 0.010, 0.0001, 0.0001 and 0.0001, respectively). CA 125 levels were statistically higher in mitral stenotic patient groups than in the control group (p < 0.0001). No statistically significant differences were shown for the other tumor markers. Group I patients had higher CA 125 levels compared to group II (p < 0.0001). CONCLUSION: Elevated CA 125 levels may be due to venous congestion and activation of peritoneal mesothelium or increased signal peptides. |
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Authors:
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Can Duman; Ertugrul Ercan; Istemihan Tengiz; Huseyin Bozdemir; H Ekin Ercan; Istemi Nalbantgil |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiology Volume: 100 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 2003 |
Date Detail:
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Created Date: 2003-09-16 Completed Date: 2004-01-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 7-10 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Biochemistry, Kocaeli University, Kocaeli, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CA-125 Antigen
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blood* Cardiac Output, Low / blood*, complications, ultrasonography Case-Control Studies Female Humans Male Middle Aged Mitral Valve Stenosis / blood*, complications, ultrasonography Prospective Studies Risk Factors Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/CA-125 Antigen; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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