Document Detail

Elevated serum C-reactive protein levels predict cardiovascular events in the Japanese coronary artery disease (JCAD) study.
MedLine Citation:
PMID:  19015587     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Accumulating evidence indicates that C-reactive protein (CRP) is an independent predictive factor for atherosclerotic vascular disease in Caucasians. Accordingly, this study sought to investigate the relationship between the serum level of CRP and cardiovascular events of Japanese patients with coronary artery disease (CAD). METHODS AND RESULTS: The Japanese CAD (JCAD) study enrolled 15,628 patients who had significant diameter stenosis (>or=75%) in at least 1 coronary artery. Of these, 6,802 patients had their baseline serum CRP data available. Patients were followed up for a mean of 2.7 years (follow-up rate 88.3%). The primary endpoint of the JCAD study was all events. Baseline covariates possibly influencing the event rate were adjusted between the 2 groups with and without elevated serum CRP level. Kaplan-Meier analysis demonstrated a 30% higher all-events rate in patients with a serum level of CRP >or=0.1 mg/dl (P=0.0002). Cox proportional hazard analysis also showed that a serum level of CRP >or=0.1 mg/dl was an independent predictor of all events (P=0.0001), and of cardiac events and cardiac death (P=0.0005). CONCLUSIONS: Elevated serum level of CRP is an independent predictor of cardiovascular events in JCAD patients.
Kenei Shimada; Masatoshi Fujita; Atsushi Tanaka; Ken Yoshida; Satoshi Jisso; Hidemasa Tanaka; Junichi Yoshikawa; Takahide Kohro; Doubun Hayashi; Yoshihiro Okada; Tsutomu Yamazaki; Ryozo Nagai;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-17
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  78-85     Citation Subset:  IM    
Department of Cardiology, Osaka Ekisaikai Hospital, Osaka, Japan.
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MeSH Terms
C-Reactive Protein / metabolism*
Cohort Studies
Coronary Artery Disease / blood*,  complications,  ethnology*
Follow-Up Studies
Heart Arrest / blood,  diagnosis*,  epidemiology
Heart Failure / blood,  diagnosis*,  epidemiology
Kaplan-Meiers Estimate
Middle Aged
Myocardial Infarction / blood,  diagnosis*,  epidemiology
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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