Document Detail

Elevated second-trimester human chorionic gonadotropin levels in association with poor pregnancy outcome.
MedLine Citation:
PMID:  7524322     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine whether abnormal pregnancy outcome is associated with elevated maternal serum human chorionic gonadotropin levels. STUDY DESIGN: Maternal serum alpha-fetoprotein and human chorionic gonadotropin levels were measured in stored second-trimester serum obtained before scheduled genetic amniocentesis from 126 women with poor pregnancy outcomes, excluding aneuploidy and structural abnormalities (complications group), and 126 matched women with normal outcomes (control group). RESULTS: More women with complications had elevated human chorionic gonadotropin levels (> or = 2.0 multiples of the median) (14%) than did control women (3%) (p = 0.01). Both elevated human chorionic gonadotropin and maternal serum alpha-fetoprotein levels were significantly associated with preterm delivery and fetal death. Elevated maternal serum alpha-fetoprotein was significantly associated with early postamniocentesis complications and fetal growth restriction, whereas elevated human chorionic gonadotropin was associated with preeclampsia. CONCLUSION: Elevated human chorionic gonadotropin, similar to unexplained elevated maternal serum alpha-fetoprotein, is significantly associated with abnormal pregnancy outcomes.
K D Wenstrom; J Owen; L R Boots; M B DuBard
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  171     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-15     Completed Date:  1994-11-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1038-41     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.
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MeSH Terms
Chorionic Gonadotropin / blood*
Fetal Death / blood
Obstetric Labor, Premature / blood
Pre-Eclampsia / blood
Pregnancy Complications / blood*
Pregnancy Outcome*
Pregnancy Trimester, Second
alpha-Fetoproteins / metabolism
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins

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