| Elevated second trimester amniotic fluid interferon gamma-inducible T-cell alpha chemoattractant concentrations as a possible predictor of preterm birth. | |
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MedLine Citation:
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PMID: 16378910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine and correlate midtrimester amniotic fluid concentrations of interferon gamma-inducible T-cell alpha chemoattractant (ITAC, a chemokine directing the migration of activated T lymphocytes toward inflammation sites) and C-reactive protein (CRP) in women undergoing amniocentesis and subsequently delivering pre-or full-term infants. METHODS: Among 312 women undergoing midtrimester transabdominal amniocentesis, 13 progressed to spontaneous delivery at less than 37 gestational weeks (GW). Subjects were matched for maternal age, parity, and GW at amniocentesis with 21 controls who delivered at greater than 37 GW. Amniotic fluid ITAC and CRP levels were determined by enzyme-linked immunosorbent assay (ELISA) and by nephelometry, respectively. RESULTS: Both ITAC and CRP values were significantly higher (P = .005 and P = .04, respectively) in the amniotic fluid of women delivering at less than 37 GW. A statistically significant correlation between amniotic fluid ITAC and CRP concentrations was also found (r = .366, P < .05). The receiver operator curve (ROC) analysis of delivery at less than 37 GW gave the best cutoff point for ITAC at a concentration of 44 pg/mL and for CRP at a concentration of 0.16 mg/dL. Positive and negative predictive values for ITAC were 82% and 85%, respectively, and for CRP, 55% and 76%, respectively. CONCLUSIONS: Present data indicate that from the second trimester of pregnancy elevated amniotic fluid concentrations of ITAC are found in women delivering at less than 37 GW, as compared to women delivering at term. Therefore, ITAC in combination with other cytokines or CRP could possibly serve as predictor of preterm delivery. |
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Authors:
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Ariadne Malamitsi-Puchner; Nikolaos Vrachnis; Evi Samoli; Stavroula Baka; Demetrios Hassiakos; George Creatsas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Society for Gynecologic Investigation Volume: 13 ISSN: 1556-7117 ISO Abbreviation: J. Soc. Gynecol. Investig. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-27 Completed Date: 2006-05-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9433806 Medline TA: J Soc Gynecol Investig Country: United States |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
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University of Athens, Medical School, Athens, Greece. malamitsi@acn.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis Amniotic Fluid / chemistry C-Reactive Protein / analysis Case-Control Studies Chemokine CXCL11 Chemokines, CXC / analysis* Enzyme-Linked Immunosorbent Assay Female Humans Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Premature Birth* |
| Chemical | |
Reg. No./Substance:
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0/CXCL11 protein, human; 0/Chemokine CXCL11; 0/Chemokines, CXC; 9007-41-4/C-Reactive Protein |
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