Document Detail

Elevated second trimester amniotic fluid interferon gamma-inducible T-cell alpha chemoattractant concentrations as a possible predictor of preterm birth.
MedLine Citation:
PMID:  16378910     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine and correlate midtrimester amniotic fluid concentrations of interferon gamma-inducible T-cell alpha chemoattractant (ITAC, a chemokine directing the migration of activated T lymphocytes toward inflammation sites) and C-reactive protein (CRP) in women undergoing amniocentesis and subsequently delivering pre-or full-term infants. METHODS: Among 312 women undergoing midtrimester transabdominal amniocentesis, 13 progressed to spontaneous delivery at less than 37 gestational weeks (GW). Subjects were matched for maternal age, parity, and GW at amniocentesis with 21 controls who delivered at greater than 37 GW. Amniotic fluid ITAC and CRP levels were determined by enzyme-linked immunosorbent assay (ELISA) and by nephelometry, respectively. RESULTS: Both ITAC and CRP values were significantly higher (P = .005 and P = .04, respectively) in the amniotic fluid of women delivering at less than 37 GW. A statistically significant correlation between amniotic fluid ITAC and CRP concentrations was also found (r = .366, P < .05). The receiver operator curve (ROC) analysis of delivery at less than 37 GW gave the best cutoff point for ITAC at a concentration of 44 pg/mL and for CRP at a concentration of 0.16 mg/dL. Positive and negative predictive values for ITAC were 82% and 85%, respectively, and for CRP, 55% and 76%, respectively. CONCLUSIONS: Present data indicate that from the second trimester of pregnancy elevated amniotic fluid concentrations of ITAC are found in women delivering at less than 37 GW, as compared to women delivering at term. Therefore, ITAC in combination with other cytokines or CRP could possibly serve as predictor of preterm delivery.
Ariadne Malamitsi-Puchner; Nikolaos Vrachnis; Evi Samoli; Stavroula Baka; Demetrios Hassiakos; George Creatsas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  13     ISSN:  1556-7117     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-27     Completed Date:  2006-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
University of Athens, Medical School, Athens, Greece.
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MeSH Terms
Amniotic Fluid / chemistry
C-Reactive Protein / analysis
Case-Control Studies
Chemokine CXCL11
Chemokines, CXC / analysis*
Enzyme-Linked Immunosorbent Assay
Predictive Value of Tests
Pregnancy Trimester, Second
Premature Birth*
Reg. No./Substance:
0/CXCL11 protein, human; 0/Chemokine CXCL11; 0/Chemokines, CXC; 9007-41-4/C-Reactive Protein

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