| Elevated satellite cell number in Duchenne muscular dystrophy. | |
| | |
MedLine Citation:
|
PMID: 20467789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The regenerative potential of muscle tissue relies mostly on satellite cells situated between the muscular basal membrane and the sarcolemma. The regeneration of muscle tissue comprises proliferation, the propagation of satellite cells, and their subsequent differentiation with the expression of multiple muscle-specific proteins. However, in Duchenne muscular dystrophy (DMD), regeneration cannot compensate for the loss of muscle tissue. To examine the regenerative potential in DMD, satellite cell nuclei number and markers of differentiation in DMD muscle from various disease states were compared with control muscle. Differentiation of satellite cells is characterized by the helix-loop-helix factor myogenin, which is never co-expressed with Pax7, whereas MyoD1 and Myf5 are co-expressed with Pax7, with Myf5 being present even in muscle of controls. The results indicate that satellite cell number is elevated in DMD in comparison with control muscle, even in advanced stages of dystrophy, suggesting that exhaustion of satellite cells is not the primary cause for failed regeneration. The expression of myogenin is correlated neither with fibrosis nor with age. We suggest variable factors influencing the differentiation of satellite cells in DMD. |
| | |
Authors:
|
Michael Kottlors; Janbernd Kirschner |
Related Documents
:
|
10439029 - Myogenic determination and differentiation of the mouse palatal muscle in relation to t... 19760789 - Cxcr4 enhances engraftment of muscle progenitor cells. 22151709 - Heart rate control via vagus nerve stimulation. 16130819 - Genetic and epigenetic control of skeletal muscle development. 9003229 - A morphometric investigation of myotube formation in rabbit embryo medial pterygoid mus... 22190549 - Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myeli... 8663099 - Identification of promoter elements involved in cell-specific regulation of rat smooth ... 7528699 - Galanin contracts and relaxes guinea pig and canine intestinal smooth muscle cells thro... 9887959 - Molecular mechanics of two smooth muscle heavy meromyosin constructs that differ by an ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-15 |
Journal Detail:
|
Title: Cell and tissue research Volume: 340 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-09 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
|
Languages: eng Pagination: 541-8 Citation Subset: IM |
Affiliation:
|
Division of Neuropediatrics and Muscle Disorders, University Children's Hospital Freiburg, Freiburg, Germany. michael.kottlors@uniklinik-freiburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Case-Control Studies Cell Count Cell Nucleus / metabolism Child Child, Preschool Humans Muscular Dystrophy, Duchenne / pathology* MyoD Protein / metabolism Myogenin / metabolism PAX7 Transcription Factor / metabolism Satellite Cells, Skeletal Muscle / pathology* |
| Chemical | |
Reg. No./Substance:
|
0/MyoD Protein; 0/Myogenin; 0/PAX7 Transcription Factor; 0/PAX7 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiplatelet therapy for atherothrombotic disease: How can we improve the outcomes?
Next Document: Masked hypertension and hidden uncontrolled hypertension after renal transplantation.