Document Detail


Elevated satellite cell number in Duchenne muscular dystrophy.
MedLine Citation:
PMID:  20467789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regenerative potential of muscle tissue relies mostly on satellite cells situated between the muscular basal membrane and the sarcolemma. The regeneration of muscle tissue comprises proliferation, the propagation of satellite cells, and their subsequent differentiation with the expression of multiple muscle-specific proteins. However, in Duchenne muscular dystrophy (DMD), regeneration cannot compensate for the loss of muscle tissue. To examine the regenerative potential in DMD, satellite cell nuclei number and markers of differentiation in DMD muscle from various disease states were compared with control muscle. Differentiation of satellite cells is characterized by the helix-loop-helix factor myogenin, which is never co-expressed with Pax7, whereas MyoD1 and Myf5 are co-expressed with Pax7, with Myf5 being present even in muscle of controls. The results indicate that satellite cell number is elevated in DMD in comparison with control muscle, even in advanced stages of dystrophy, suggesting that exhaustion of satellite cells is not the primary cause for failed regeneration. The expression of myogenin is correlated neither with fibrosis nor with age. We suggest variable factors influencing the differentiation of satellite cells in DMD.
Authors:
Michael Kottlors; Janbernd Kirschner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-15
Journal Detail:
Title:  Cell and tissue research     Volume:  340     ISSN:  1432-0878     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  541-8     Citation Subset:  IM    
Affiliation:
Division of Neuropediatrics and Muscle Disorders, University Children's Hospital Freiburg, Freiburg, Germany. michael.kottlors@uniklinik-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Case-Control Studies
Cell Count
Cell Nucleus / metabolism
Child
Child, Preschool
Humans
Muscular Dystrophy, Duchenne / pathology*
MyoD Protein / metabolism
Myogenin / metabolism
PAX7 Transcription Factor / metabolism
Satellite Cells, Skeletal Muscle / pathology*
Chemical
Reg. No./Substance:
0/MyoD Protein; 0/Myogenin; 0/PAX7 Transcription Factor; 0/PAX7 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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