Document Detail


Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States.
MedLine Citation:
PMID:  18224690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Registry Study. We calculated standardized incidence ratios (SIRs) to estimate excess risk for SCCC, primary ocular lymphoma, ocular Kaposi sarcoma (KS) and other eye tumors among 491, 048 adults (aged > 15 years or older) with HIV/AIDS diagnosed from 1980 to 2004. We calculated relative proportions (per 10(5)) to gain insight into risk factors. We identified 73 eye cancers (15 SCCC, 35 primary ocular lymphoma, 17 ocular KS and 6 other). Overall SIRs were elevated for SCCC (SIR, 12.2, 95% CI 6.8-20.2), primary ocular lymphoma (21.7, 95% CI 15.1-30.2) and ocular KS (109, 95% CI 63.5-175). Risk for SCCC was elevated regardless of HIV acquisition category, CD4 lymphocyte count and time relative to AIDS-onset. Relative proportions of SCCC risk were highest with age >or=50 (8/10(5)), Hispanic ethnicity (7/10(5)) and residence in regions with high-solar ultraviolet radiation (10/10(5)). We show significantly increased incidence of SCCC among persons with HIV/AIDS in the U.S. The associations with age and geography are in accord with etiological role for ultraviolet radiation in SCCC.
Authors:
Mercy Guech-Ongey; Eric A Engels; James J Goedert; Robert J Biggar; Sam M Mbulaiteye
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  122     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2590-3     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. guechome@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications
Adolescent
Adult
Age Factors
Carcinoma, Squamous Cell / epidemiology*,  ethnology,  virology*
Conjunctival Neoplasms / epidemiology*,  ethnology,  virology*
Female
HIV Infections / complications*
Hispanic Americans / statistics & numerical data
Humans
Immunocompromised Host
Incidence
Lymphoma / epidemiology,  virology
Male
Middle Aged
Odds Ratio
Registries
Risk Assessment
Risk Factors
Sarcoma, Kaposi / epidemiology,  virology
Ultraviolet Rays / adverse effects
United States / epidemiology
Grant Support
ID/Acronym/Agency:
N01-CO-12400/CO/NCI NIH HHS; N02-CP-31003/CP/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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