Document Detail


Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans.
MedLine Citation:
PMID:  15472204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Activation of central nervous mineralocorticoid receptors (MRs) has been shown to inhibit the activity of the hypothalamo-pituitary-adrenocortical (HPA) axis in animals. Here, we examined whether MRs in humans likewise regulate HPA activity in response to a physiological stressor. In a balanced, randomized, double-blind, cross-over trial, 12 healthy men were treated with either two injections of 200 mg canrenoate or placebo 24 and 8 h before an intense physical exercise taking place between 1600 and 1700 h. Exercising was preceded by a 60-min rest period and followed by another 90-min rest. Blood was collected in regular intervals to determine ACTH, cortisol, and human GH (hGH). Exercise induced a significant rise in cortisol, ACTH, and hGH. Cortisol levels, however, were significantly higher after canrenoate, compared with placebo, whereas ACTH and hGH concentrations did not differ. The increase in cortisol was already significant during rest before exercise and continued to be elevated throughout the whole experiment. We conclude that MR blockade leads to a tonically increased cortisol secretion both during rest and under stimulation. The undiminished concentration of ACTH in the presence of elevated cortisol levels suggests that blockade of MR shifts the set point for cortisol feedback inhibition of the HPA axis toward higher cortisol levels.
Authors:
Peter Wellhoener; Jan Born; Horst L Fehm; Christoph Dodt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-08     Completed Date:  2004-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5048-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine I, University Hospital Schleswig Holstein, D-23538 Luebeck, Germany. peter.wellhoener@innere1.uni-luebeck.de <peter.wellhoener@innere1.uni-luebeck.de>
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Adult
Aldosterone Antagonists / administration & dosage*
Canrenoate Potassium / administration & dosage*
Cross-Over Studies
Double-Blind Method
Exercise
Human Growth Hormone / blood
Humans
Hydrocortisone / blood*
Hypothalamo-Hypophyseal System / drug effects
Male
Pituitary-Adrenal System / drug effects
Receptors, Mineralocorticoid / antagonists & inhibitors*
Rest
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Receptors, Mineralocorticoid; 12629-01-5/Human Growth Hormone; 2181-04-6/Canrenoate Potassium; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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