Document Detail

Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia.
MedLine Citation:
PMID:  17396727     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if red cell distribution width (RDW) is elevated in thrombotic thrombocytopenic purpura (TTP) and to evaluate the sensitivity and specificity of such elevation in the diagnosis of TTP. METHODS: We retrospectively studied red cell distribution width at presentation in 25 consecutive patients with newly diagnosed TTP who were treated with plasmapheresis in our institution between 1997 to 2005. Control patients consisted of 20 consecutive patients without TTP who presented to the emergency room (ER) with anemia and thrombocytopenia. RESULTS: Patients with TTP had significantly elevated RDW compared with the controls (23.1% versus 17.2% respectively, P = 0.0001). An RDW > 18% had a 95% sensitivity and 70% specificity in the diagnosis of TTP, whereas RDW > 19% had 80% sensitivity and 85% specificity. CONCLUSIONS: TTP should be suspected in patients presenting with unexplained anemia and thrombocytopenia with an RDW > or = 18%.
Nagaprasad Nagajothi; Albert Braverman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  100     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-9     Citation Subset:  AIM; IM    
Department of Hematology/Oncology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
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MeSH Terms
Anemia, Hemolytic / blood*,  diagnosis
Cell Size
Diagnosis, Differential
Erythrocyte Indices*
Erythrocytes / pathology
Hemoglobins / analysis
Platelet Count
Purpura, Thrombocytopenic, Idiopathic / blood,  diagnosis
Purpura, Thrombotic Thrombocytopenic / blood*,  diagnosis
Retrospective Studies
Sensitivity and Specificity
Thrombocytopenia / blood*,  diagnosis
Reg. No./Substance:

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