Document Detail

Elevated pulse pressure is associated with age-related decline in language ability.
MedLine Citation:
PMID:  20663268     Owner:  NLM     Status:  MEDLINE    
Recent research suggests that pulse pressure (PP), a putative marker of vascular integrity, may be associated with brain microvascular damage and age-related cognitive decline. Thus, the present study examined the relationship between PP and cognition in a sample of healthy nondemented older adults. One hundred nine participants were administered neurological and neuropsychological evaluations and determined to be nondemented. Regression analyses were used to examine the relationships among pulse pressure (PP) [systolic blood pressure (SBP)--diastolic blood pressure (DBP)], age, and cognition. PP and related measures were inversely correlated with global cognitive functioning and scores on a composite measure of language function, even after adjusting for age, education, and relevant vascular risk factors. Results indicate that increases in the pulsatile component of blood pressure may convey added risk of global cognitive decline and specific impairment in language abilities.
D A Nation; C E Wierenga; L Delano-Wood; A J Jak; D C Delis; D P Salmon; M W Bondi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-07-21
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  16     ISSN:  1469-7661     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-02-17     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  933-8     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Attention / physiology
Blood Pressure / physiology*
Hemodynamics / physiology
Language Development Disorders / complications*
Middle Aged
Risk Factors
Statistics as Topic
Stroke / epidemiology
Grant Support
K24 AG026431/AG/NIA NIH HHS; K24 AG026431/AG/NIA NIH HHS; K24 AG026431-01A2/AG/NIA NIH HHS; MH18399/MH/NIMH NIH HHS; P50 AG05131/AG/NIA NIH HHS; R01 AG012674/AG/NIA NIH HHS; R01 AG012674/AG/NIA NIH HHS; R01 AG012674-06A2/AG/NIA NIH HHS

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