Document Detail

Elevated prothrombin and activated protein C resistance in patients with thoracic aortic atheroma.
MedLine Citation:
PMID:  12143947     Owner:  NLM     Status:  MEDLINE    
Patients with protruding aortic atheroma containing mobile emboli are at risk for peripheral emboli and stroke. This risk may possibly be reduced by anticoagulation, but whether or not such patients have an increased prevalence of thrombotic risk factors has not been previously determined. Twenty-two patients were studied (11 with protruding thoracic aortic atheromas and superimposed mobile thrombi on transesophageal echocardiography were compared to 11 age-matched controls). The authors evaluated activated protein C resistance (APC-R) by measuring the prolongation of the partial thromboplastin time (PTT) in response to activated protein C (APC). Concentrations of fibrinogen, antithrombin III (AT III), factor II, factor V, and D-dimer were also determined in all patients. There was significant resistance to APC (a smaller prolongation in PTT) in patients with atheromas and thrombi. They also had significantly higher concentrations of factor II. Factor V and fibrinogen were higher, and AT III lower, in patients than in controls; however, these latter differences did not reach statistical significance. Patients with aortic atheroma and mobile thrombi may have an increased prevalence of thrombotic risk factors. There is significantly increased resistance to activated protein C in patients with protruding atheroma and mobile thrombi in their thoracic aorta. There was also a trend toward elevated fibrinogen, homocysteine, and apo (a) concentrations as well as lower antithrombin III concentrations in these patients.
Peter Lochow; Arthur Schwartzbard; Judy Guest; Carolyn Ripps; Daniel Matalon; Rosemary Gambetta; Paul A Tunick; Steven Sedlis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  53     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Department of Cardiology, Veterans Affairs Medical Center New York, NY, USA.
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MeSH Terms
Aorta, Thoracic
Aortic Diseases / blood*
Arteriosclerosis / blood*
Pilot Projects
Protein C / metabolism*
Prothrombin / analysis*
Risk Factors
Reg. No./Substance:
0/Protein C; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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