Document Detail


Elevated procalcitonin and C-reactive protein as potential biomarkers of sepsis in a subpopulation of thrombotic microangiopathy patients.
MedLine Citation:
PMID:  19591197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombotic microangiopathy (TMA) comprises a group of microvascular thrombosis syndromes associated with multiple pathogenic factors. Deficient activity of ADAMTS13 is a pathogenic factor in a subset of TMA patients that provides a strong rationale for plasma exchange treatment. However, the subset of TMA patients with normal ADAMTS13 activity remains a heterogeneous group of patients in which the appropriate treatment is not well understood. In addition to the common forms of TMA thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome, the differential diagnosis of TMA may include sepsis, autoimmune disorders, and disseminated intravascular coagulation. Optimal treatment of TMA depends on timely recognition of treatable pathogenic factors. We hypothesized that sepsis is a rapidly identifiable pathogenic factor in a subset of TMA patients. To test this hypothesis, we retrospectively measured the rapid biomarkers of sepsis C-reactive protein (CRP) and procalcitonin (PCT), in a repository of pretreatment plasma samples from 61 TMA patients treated with plasma exchange. Levels were analyzed in 31 severely ADAMTS13-deficient and 30 ADAMTS13-normal patients. None of the 31 patients with severe deficiency of ADAMTS13 had elevated PCT. However, 11 of 30 (37%) non-ADAMTS13-deficient patient samples were strongly positive for PCT. These patient samples also had a >10-fold higher median CRP level than patients with normal PCT. We conclude that rapid assays may help identify sepsis in a subset of TMA patients.
Authors:
Yasuko O Erickson; Noelle I Samia; Bruce Bedell; Kenneth D Friedman; Bonnie S Atkinson; Thomas J Raife
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  24     ISSN:  1098-1101     ISO Abbreviation:  J Clin Apher     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-10-22     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-4     Citation Subset:  IM    
Affiliation:
The Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins / blood
Biological Markers
C-Reactive Protein / analysis*
Calcitonin / blood*
Hemolytic-Uremic Syndrome / blood*
Humans
Protein Precursors / blood*
Purpura, Thrombotic Thrombocytopenic / blood*
Retrospective Studies
Sepsis / blood*,  diagnosis
Grant Support
ID/Acronym/Agency:
HL-02-001/HL/NHLBI NIH HHS; HL-55556/HL/NHLBI NIH HHS; HL-62984/HL/NHLBI NIH HHS; R01 HL055556-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin; 9007-41-4/C-Reactive Protein; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human
Comments/Corrections

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