Document Detail


Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome.
MedLine Citation:
PMID:  20027679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.
METHODS: Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC/MS) and metabolomics (GC x GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.
RESULTS: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di- and triacylglycerols. Among the metabolites, the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03).
CONCLUSION: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.
Authors:
Kajsa Kajander; Eveliina Myllyluoma; Sinikka Kyrönpalo; Martin Rasmussen; Pentti Sipponen; Ismo Mattila; Tuulikki Seppänen-Laakso; Heikki Vapaatalo; Matej Oresic; Riitta Korpela
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-22     Completed Date:  2010-03-18     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  6068-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Case-Control Studies
Female
Humans
Intestinal Mucosa / metabolism*
Irritable Bowel Syndrome / metabolism*,  physiopathology
Lipid Metabolism*
Male
Metabolomics
Middle Aged
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