Document Detail

Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome.
MedLine Citation:
PMID:  20027679     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.
METHODS: Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC/MS) and metabolomics (GC x GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.
RESULTS: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di- and triacylglycerols. Among the metabolites, the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03).
CONCLUSION: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.
Kajsa Kajander; Eveliina Myllyluoma; Sinikka Kyrönpalo; Martin Rasmussen; Pentti Sipponen; Ismo Mattila; Tuulikki Seppänen-Laakso; Heikki Vapaatalo; Matej Oresic; Riitta Korpela
Related Documents :
9822319 - Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two...
16116529 - Clinical evaluation of the use of the m2a patency capsule system before a capsule endos...
9655269 - The changing face of mesenteric infarction.
3105959 - Hypoalbuminemia as an indicator of diarrheal incidence in critically ill patients.
21486929 - Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus...
3319029 - Small bowel obstruction: computer-assisted prediction of strangulation at presentation.
2571019 - Upper gastrointestinal cancer in patients with familial adenomatous polyposis.
3445879 - Airway hyperreactivity and menstrual cycle in asthmatic patients.
15206829 - Interactions among a stressor, self-efficacy, coping with stress, depression, and anxie...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  15     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-22     Completed Date:  2010-03-18     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  6068-74     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Intestinal Mucosa / metabolism*
Irritable Bowel Syndrome / metabolism*,  physiopathology
Lipid Metabolism*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer.
Next Document:  Wireless capsule endoscopy in detecting small-intestinal polyps in familial adenomatous polyposis.