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Elevated pretreatment levels of soluble CD8 and Beta-2-microglobulin as indicators of relapse in breast-cancer patients.
MedLine Citation:
PMID:  21566948     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We measured soluble CD8 ((S)CD8) and microglobulin (beta-2M) in 128 breast cancer patients and in 200 controls by the ELISA method. Patient groups were: Group A-new patients; Group B-patients on follow-up; Group C-patients with metastases. The mean (S)CD8 and beta-2M were significantly higher in patients than in controls ((S)CD8 p<0.01, beta-2M p<0.0001). Both for (S)CD8 and beta-2M, groups A and C had high levels which differed significantly from Group B ((S)CD8 p<0.04; beta-2M p<0.0001). A significant correlation between (S)CD8 and B-2M was observed (r=0.379: p=0.0001). Twenty patients relapsed. In 14/20 (70%) an initial high (S)CD8 and in 10/20 (50%), high beta-2M was observed. High initial CD8 and beta-2M were able to identify 80% of relapsed patients. High (S)CD8 and beta-2M levels are indicative of tumor bulk and are able to identify patients at.
Authors:
B Klein; I Levin; H Lurie; A Nyska; J Shapira; M Kravits; T Klein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  4     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  2011-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  -    
Affiliation:
SOROKA HOSP,DEPT UROL,BEER SHEVA,ISRAEL. BEILINSON MED CTR,DEPT ONCOL,IL-49100 PETAH TIQWA,ISRAEL. KIMRON VET INST,BET DAGAN,ISRAEL. MEIR HOSP,ONCOL UNIT,KEFAR SAVA,ISRAEL. TEL AVIV UNIV,BEILINSON MED CTR,TISSUE TYPING LAB,TEL AVIV,ISRAEL. TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL.
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