| Elevated E/E' predicts prognosis in congestive heart failure patients with preserved systolic function. | |
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MedLine Citation:
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PMID: 19015586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although approximately 50% of heart failure patients are reported as heart failure with preserved left ventricular systolic function (HFPSF), echocardiographic prognostic predictors have not been well investigated. Recently, the tissue Doppler-derived index, the ratio of the early transmitral flow velocity and the early mitral annular velocity (E/E'), was reported as useful in predicting prognosis of patients with heart diseases. The purpose of this study was to investigate whether E/E' predicts prognosis in HFPSF. METHODS AND RESULTS: A total of 50 patients with HFPSF (ejection fraction >50%) were consecutively enrolled and studied. Echocardiographic examination was performed on admission and repeated after optimized medical therapy. Cardiac events were defined as death and unplanned hospitalization because of congestive heart failure. Cardiac event-free survival curves from patients with E/E' >15 and E/E' <or=15 at baseline did not differ. On the other hand, patients with E/E' >15 after medical therapy showed significantly lower cardiac event-free survival than patients with E/E' <or=15 (log-rank, P=0.005). By multivariate logistic regression analysis, E/E' >15 after medical therapy was the only independent predictor of cardiac events (P=0.037, risk ratio=6.1, 95% confidence interval: 1.12-33.3) in patients with HFPSF. CONCLUSIONS: Elevated E/E' after optimized medical therapy may be useful in predicting cardiac events in patients with HFPSF. |
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Authors:
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Hiroyuki Okura; Tomoichiro Kubo; Koichiro Asawa; Iku Toda; Minoru Yoshiyama; Junichi Yoshikawa; Kiyoshi Yoshida |
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Publication Detail:
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Type: Journal Article Date: 2008-11-17 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-26 Completed Date: 2009-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 86-91 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Bell Land General Hospital, Sakai, Japan. hokura@fides.dti.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Flow Velocity / physiology Blood Pressure / physiology* Echocardiography, Doppler, Pulsed Female Follow-Up Studies Heart Failure / diagnosis*, physiopathology* Heart Ventricles / physiopathology Humans Kaplan-Meiers Estimate Logistic Models Male Middle Aged Mitral Valve / physiopathology* Predictive Value of Tests Prognosis Retrospective Studies Systole / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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