Document Detail

Elevated E/E' predicts prognosis in congestive heart failure patients with preserved systolic function.
MedLine Citation:
PMID:  19015586     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although approximately 50% of heart failure patients are reported as heart failure with preserved left ventricular systolic function (HFPSF), echocardiographic prognostic predictors have not been well investigated. Recently, the tissue Doppler-derived index, the ratio of the early transmitral flow velocity and the early mitral annular velocity (E/E'), was reported as useful in predicting prognosis of patients with heart diseases. The purpose of this study was to investigate whether E/E' predicts prognosis in HFPSF. METHODS AND RESULTS: A total of 50 patients with HFPSF (ejection fraction >50%) were consecutively enrolled and studied. Echocardiographic examination was performed on admission and repeated after optimized medical therapy. Cardiac events were defined as death and unplanned hospitalization because of congestive heart failure. Cardiac event-free survival curves from patients with E/E' >15 and E/E' <or=15 at baseline did not differ. On the other hand, patients with E/E' >15 after medical therapy showed significantly lower cardiac event-free survival than patients with E/E' <or=15 (log-rank, P=0.005). By multivariate logistic regression analysis, E/E' >15 after medical therapy was the only independent predictor of cardiac events (P=0.037, risk ratio=6.1, 95% confidence interval: 1.12-33.3) in patients with HFPSF. CONCLUSIONS: Elevated E/E' after optimized medical therapy may be useful in predicting cardiac events in patients with HFPSF.
Hiroyuki Okura; Tomoichiro Kubo; Koichiro Asawa; Iku Toda; Minoru Yoshiyama; Junichi Yoshikawa; Kiyoshi Yoshida
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Publication Detail:
Type:  Journal Article     Date:  2008-11-17
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
Division of Cardiology, Bell Land General Hospital, Sakai, Japan.
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MeSH Terms
Aged, 80 and over
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Echocardiography, Doppler, Pulsed
Follow-Up Studies
Heart Failure / diagnosis*,  physiopathology*
Heart Ventricles / physiopathology
Kaplan-Meiers Estimate
Logistic Models
Middle Aged
Mitral Valve / physiopathology*
Predictive Value of Tests
Retrospective Studies
Systole / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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