Document Detail

Elevated postmortem tryptase in the absence of anaphylaxis.
MedLine Citation:
PMID:  7602279     Owner:  NLM     Status:  MEDLINE    
Elevations in tryptase, a recently discovered mast cell enzyme, have been proposed as a postmortem indicator of fatal anaphylaxis. The previous studies had limited numbers of controls and thus the specificity of the test with postmortem samples was not known. Therefore, tryptase was evaluated in postmortem blood samples from 49 autopsy cases where there was no evidence of fatal anaphylaxis. The tryptase was above the normal serum threshold of 1 nanogram/mL (ng/mL) in 31 of these cases. Twenty-four cases had values in the 1 to 5 ng/mL range, two cases were between 5 and 10 ng/mL, and five were greater than 10 ng/mL. One autopsy specimen had a tryptase value of 106 ng/mL. The postmortem interval and the specimen storage condition did not appear to correlate with these elevations in tryptase. Although elevations in the postmortem tryptase remain an important supporting finding in the diagnosis of fatal anaphylaxis, it should not be used alone as the sole criterion for the postmortem diagnosis of anaphylaxis.
B Randall; J Butts; J F Halsey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  40     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-07     Completed Date:  1995-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  IM    
University of South Dakota School of Medicine, Department of Laboratory Medicine, Sioux Falls, USA.
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MeSH Terms
Aged, 80 and over
Anaphylaxis / enzymology*
Cause of Death
Child, Preschool
Mast Cells / enzymology*
Middle Aged
Postmortem Changes*
Serine Endopeptidases / blood*
Thioridazine / poisoning
Reg. No./Substance:
50-52-2/Thioridazine; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/chymase 2; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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