| Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. | |
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MedLine Citation:
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PMID: 10940274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying. AIM: To investigate if GLP-1 and GLP-2 contribute to the positive effects of a preserved colon in short bowel patients by measuring circulating levels of GLP-1 and GLP-2 in seven ileum resected short bowel patients with a preserved colon and seven age and sex matched controls. METHODS: GLP-1 and GLP-2 immunoreactivity was measured by specific radioimmunoassays in plasma collected at fasting and at regular intervals 180 minutes after a test meal. RESULTS: Median (25-75%) fasting GLP-2 values were 72 (69-105) pmol/l versus 23 (19-27) pmol/l (p=0.001) and meal stimulated area under the curve was 21 078 (14 811-26 610) min x pmol/l versus 11 150 (7151-12 801) min x pmol/l (p=0.01) in short bowel patients with a preserved colon compared with control subjects. Fasting GLP-1 values were 10 (6-12) pmol/l versus 5 (3-5) pmol/l (p=0.01) and meal stimulated area under the curve was 3418 (2966-6850) min x pmol/l versus 2478 (1929-3199) min x pmol/l (p=0.04), respectively. CONCLUSION: Ileum resected short bowel patients with a preserved colon had elevated fasting plasma concentrations of GLP-1 and GLP-2 and significantly larger meal stimulated areas under the curve compared with age and sex matched controls. Elevated GLP-1 and GLP-2 concentrations may contribute to the positive effects of a preserved colon on intestinal motility and functional adaptation in ileum resected short bowel patients. |
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Authors:
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P B Jeppesen; B Hartmann; J Thulesen; B S Hansen; J J Holst; S S Poulsen; P B Mortensen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 47 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-09-21 Completed Date: 2000-09-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine CA-2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark. Bekker@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adult Aged Area Under Curve Case-Control Studies Fasting / blood, metabolism Female Glucagon / blood* Glucagon-Like Peptide 1 Glucagon-Like Peptide 2 Humans Ileum / physiology, surgery Male Middle Aged Peptide Fragments / blood* Peptides / blood* Postprandial Period Protein Precursors / blood* Radioimmunoassay Short Bowel Syndrome / blood*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Glucagon-Like Peptide 2; 0/Peptide Fragments; 0/Peptides; 0/Protein Precursors; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon |
| Comments/Corrections | |
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