Document Detail

Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon.
MedLine Citation:
PMID:  10940274     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying. AIM: To investigate if GLP-1 and GLP-2 contribute to the positive effects of a preserved colon in short bowel patients by measuring circulating levels of GLP-1 and GLP-2 in seven ileum resected short bowel patients with a preserved colon and seven age and sex matched controls. METHODS: GLP-1 and GLP-2 immunoreactivity was measured by specific radioimmunoassays in plasma collected at fasting and at regular intervals 180 minutes after a test meal. RESULTS: Median (25-75%) fasting GLP-2 values were 72 (69-105) pmol/l versus 23 (19-27) pmol/l (p=0.001) and meal stimulated area under the curve was 21 078 (14 811-26 610) min x pmol/l versus 11 150 (7151-12 801) min x pmol/l (p=0.01) in short bowel patients with a preserved colon compared with control subjects. Fasting GLP-1 values were 10 (6-12) pmol/l versus 5 (3-5) pmol/l (p=0.01) and meal stimulated area under the curve was 3418 (2966-6850) min x pmol/l versus 2478 (1929-3199) min x pmol/l (p=0.04), respectively. CONCLUSION: Ileum resected short bowel patients with a preserved colon had elevated fasting plasma concentrations of GLP-1 and GLP-2 and significantly larger meal stimulated areas under the curve compared with age and sex matched controls. Elevated GLP-1 and GLP-2 concentrations may contribute to the positive effects of a preserved colon on intestinal motility and functional adaptation in ileum resected short bowel patients.
P B Jeppesen; B Hartmann; J Thulesen; B S Hansen; J J Holst; S S Poulsen; P B Mortensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  47     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-21     Completed Date:  2000-09-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  AIM; IM    
Department of Medicine CA-2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark.
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MeSH Terms
Adaptation, Physiological
Area Under Curve
Case-Control Studies
Fasting / blood,  metabolism
Glucagon / blood*
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Ileum / physiology,  surgery
Middle Aged
Peptide Fragments / blood*
Peptides / blood*
Postprandial Period
Protein Precursors / blood*
Short Bowel Syndrome / blood*,  surgery
Reg. No./Substance:
0/Glucagon-Like Peptide 2; 0/Peptide Fragments; 0/Peptides; 0/Protein Precursors; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

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