Document Detail

Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil.
MedLine Citation:
PMID:  20206485     Owner:  NLM     Status:  MEDLINE    
The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16-62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of alpha-linolenic acid (alpha-LLA) was doubled. Efficient competitive inhibition by alpha-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6-3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.
T Seppänen-Laakso; I Laakso; T Lehtimäki; R Rontu; E Moilanen; T Solakivi; L Seppo; H Vanhanen; K Kiviranta; R Hiltunen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-04
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  83     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  45-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland.
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MeSH Terms
Fatty Acids, Monounsaturated / administration & dosage*
Fatty Acids, Omega-6 / blood*
Fibrinogen / analysis*,  metabolism
Middle Aged
Phospholipids / blood
Time Factors
alpha-Linolenic Acid / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-6; 0/Phospholipids; 120962-03-0/canola oil; 463-40-1/alpha-Linolenic Acid; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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