Document Detail


Elevated plasma apolipoprotein AV in acute coronary syndrome is positively correlated with triglyceride and C-reactive protein.
MedLine Citation:
PMID:  19567162     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increased triglyceride (TG) occurs in patients with acute coronary syndrome (ACS), and apolipoprotein AV (apoAV) has been shown to lower TG levels. In the present study, we investigated plasma apoAV level and its relationship with TG and C-reactive protein (CRP) in ACS patients. METHODS: A total of 459 subjects were recruited and categorized into control group (n = 116), stable angina (SA) group (n = 115), unstable angina group (n = 116) and acute myocardial infarction group (n = 112). Plasma apoAV level was measured by a sandwich ELISA assay. RESULTS: Compared with controls ((100.27 +/- 22.44) ng/ml), plasma apoAV was decreased in SA patients ((76.54 +/- 16.91) ng/ml) but increased in patients with unstable angina ((330.89 +/- 66.48) ng/ml, P < 0.05) or acute myocardial infarction ((368.66 +/- 60.53) ng/ml, P < 0.05). Inverse correlations between apoAV and TG were observed in the control or stable angina groups (r = -0.573 or -0.603, respectively, P < 0.001), whereas positive correlations were observed in the patients with unstable angina or acute myocardial infarction (r = 0.696 or 0.690, respectively, P < 0.001). Furthermore, a positive relationship between apoAV and CRP was observed in the ACS patients but not in the non-ACS subjects. CONCLUSION: The plasma apoAV concentration is increased and positively correlates with TG and CRP in ACS patients.
Authors:
Xian-Sheng Huang; Shui-Ping Zhao; Qian Zhang; Lin Bai; Min Hu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  122     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1408-12     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*,  metabolism
Adult
Aged
Apolipoproteins A / blood*
C-Reactive Protein / metabolism*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/APOA5 protein, human; 0/Apolipoproteins A; 0/Triglycerides; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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