Document Detail


Elevated plasma adiponectin and decreased plasma homocysteine and asymmetric dimethylarginine in children with type 1 diabetes.
MedLine Citation:
PMID:  18830896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Type 1 diabetes has a bad prognosis concerning the pathogenesis of cardiovascular diseases (CVD). The purpose of this study was to evaluate different possible new risk indices for CVD in children with type 1 diabetes. MATERIAL AND METHODS: The present study included 30 children with diabetes (mean HbA1C 9.8%), aged between 4.7 and 18.6 years and with no clinical evidence of vascular complications, and 30 healthy subjects matched by sex, age and body mass index. Blood pressure was measured and blood samples were obtained for lipid profile, creatinine, glucose, high sensitive C-reactive protein (hsCRP), intercellular adhesion molecule-1 (ICAM-1), asymmetric dimethylarginine (ADMA), adiponectin and homocysteine. RESULTS: Children with diabetes had significantly higher blood pressure, plasma hsCRP, ICAM-1, adiponectin levels and lower homocysteine, ADMA concentrations than their control subjects. In multivariate regression analysis, the best predictors for systolic blood pressure were diabetes group, plasma homocysteine concentration and BMI (Adj R(2) = 0.38, p<0.0001), and for diastolic blood pressure diabetes group and triglycerides level (Adj R(2) = 0.27, p<0.0001). CONCLUSIONS: Children with diabetes, in view of their higher future risk of CVD, are characterized by a higher concentration of protective adiponectin and paradoxically lower blood concentrations of some other possible risk markers of atherosclerosis, i.e. ADMA and homocysteine compared to healthy children.
Authors:
Kaire Heilman; Mihkel Zilmer; Kersti Zilmer; Pille Kool; Vallo Tillmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  69     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of Tartu, Tartu, Estonia. Kaire.Heilman@kliinikum.ee
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Adolescent
Arginine / analogs & derivatives*,  blood
C-Reactive Protein / analysis
Case-Control Studies
Child
Child, Preschool
Confidence Intervals
Diabetes Mellitus, Type 1 / blood*
Female
Homocysteine / blood*
Humans
Intercellular Adhesion Molecule-1 / blood
Male
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Adiponectin; 126547-89-5/Intercellular Adhesion Molecule-1; 30315-93-6/N,N-dimethylarginine; 454-28-4/Homocysteine; 74-79-3/Arginine; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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