Document Detail


Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.
MedLine Citation:
PMID:  25202347     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Esophageal squamous cell carcinoma (ESCC) is the most common histological subtype of esophageal cancer and one of the most aggressive types of malignancy, with a high rate of mortality. Early diagnosis and treatment may improve the prognosis of ESCC and, thus, survival rates. As a significant tumor suppressor, p53 is closely associated with apoptosis and the differentiation of cancer cells. The present study evaluated the expression levels of the p53 protein and the clinical significance in patients presenting with ESCC. The p53 protein expression level of 64 paired ESCC and tumor-adjacent normal tissues was evaluated using western blot analysis. In addition, immunohistochemistry (IHC) was performed to detect the p53 expression level in specimens from 118 paraffin-embedded cancerous tissues. The correlation of the p53 expression level with the clinicopathological parameters and prognosis of the ESCC patients was also analyzed. The p53 protein was identified to be highly expressed in the ESCC tissue, with western blot analysis demonstrating that the expression level of p53 in the cancerous tissue was 1.89 times that of the tumor-adjacent normal tissue (P<0.001); furthermore, IHC indicated that there was a marked positive expression of p53 in the ESCC tissue (49.15%). The expression level of p53 protein was identified to be significantly correlated with the tumor grade (P<0.001), N stage (P=0.010). Additionally, the higher level of p53 expression was found to be associated with a poor survival rate in the ESCC patients (P=0.0404). The univariate analysis showed that the survival time of patients was significantly correlated with the T stage (RR=3.886, P<0.001), N stage (lymph node metastasis; RR=3.620, P<0.001) and TNM stage (RR=3.576, P<0.001). Furthermore, the multivariate analysis revealed that the T stage (RR=3.988, P<0.001) and N stage (RR=4.240, P=0.004) significantly influenced the overall survival of the ESCC patients.
Authors:
Kate Huang; Lin Chen; Jiliang Zhang; Zhi Wu; Linhua Lan; Lu Wang; Bin Lu; Yongzhang Liu
Related Documents :
25165357 - Sox2 identifies the treatment-refractory stem cell population in group 2 medulloblastoma.
22101747 - Paraganglioma of the facial nerve, a rare differential diagnosis for facial nerve paral...
9888707 - Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site.
25416827 - The long-term risk of malignant astrocytic tumors after structural brain injury-a natio...
6861157 - Tamoxifen-induced fluorescence as a marker of human breast tumor cell responsiveness to...
3488007 - The use of flow cytometry in the diagnosis and biological characterization of the non-h...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-11
Journal Detail:
Title:  Oncology letters     Volume:  8     ISSN:  1792-1074     ISO Abbreviation:  Oncol Lett     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1441-1446     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  GSTM3 reverses the resistance of hepatoma cells to radiation by regulating the expression of cell cy...
Next Document:  Phospho-mTOR in non-tumour and tumour bladder urothelium: Pattern of expression and impact on urothe...